WormBase Tree Display for Gene: WBGene00006875
expand all nodes | collapse all nodes | view schema
WBGene00006875 | Evidence | Paper_evidence | WBPaper00005969 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T22C8 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | vab-9 | Person_evidence | WBPerson261 | |||||
Sequence_name | T22C8.8 | ||||||||
Molecular_name | T22C8.8 | ||||||||
T22C8.8.1 | |||||||||
CE32938 | |||||||||
Other_name | CELE_T22C8.8 | Accession_evidence | NDB | BX284602 | |||||
Public_name | vab-9 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | vab | ||||||||
Reference_allele | WBVar00144274 | ||||||||
Allele (27) | |||||||||
Legacy_information | e1744 : slightly dumpy tail whip knobbed at all stages except adult male (adult male tail tip slightly swollen); variably Egl. ES3 (larvae) ME2. NA3 (e1775 e2016 : resemble e1744 slightly dumpier). | ||||||||
See also e1744, e1775, e2016 | |||||||||
[C.elegansII] e1744 : slightly dumpy, tail whip knobbed at all stages except adult male (adult male tail tip slightly swollen); variably Egl. ES3 (larvae) ME2. OA2: e1775, e2016 (resemble e1744, slightly dumpier). [Hodgkin 1974] | |||||||||
Strain | WBStrain00004468 | ||||||||
WBStrain00007740 | |||||||||
WBStrain00007742 | |||||||||
WBStrain00007743 | |||||||||
WBStrain00031259 | |||||||||
WBStrain00031254 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00013081 | ||||||||
00013082 | |||||||||
00013083 | |||||||||
00013084 | |||||||||
00013085 | |||||||||
00013086 | |||||||||
00013087 | |||||||||
00013088 | |||||||||
00013089 | |||||||||
00114959 | |||||||||
Ortholog (38) | |||||||||
Structured_description | Concise_description | vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization. | Paper_evidence | WBPaper00000608 | |||||
WBPaper00004961 | |||||||||
WBPaper00005946 | |||||||||
WBPaper00005969 | |||||||||
WBPaper00005975 | |||||||||
WBPaper00012856 | |||||||||
WBPaper00012883 | |||||||||
WBPaper00018356 | |||||||||
Person_evidence | WBPerson261 | ||||||||
Curator_confirmed | WBPerson13481 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Involved in cell-cell adhesion; defense response to Gram-negative bacterium; and innate immune response. Located in cell junction. Expressed in epithelial cell; hypodermis; and nerve ring. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Is an ortholog of human TMEM47 (transmembrane protein 47). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0112011 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17637) | ||||
DOID:0050467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17637) | ||||||
Molecular_info | Corresponding_CDS | T22C8.8 | |||||||
Corresponding_CDS_history | T22C8.8:wp92 | ||||||||
Corresponding_transcript | T22C8.8.1 | ||||||||
Other_sequence (22) | |||||||||
Associated_feature (12) | |||||||||
Experimental_info | RNAi_result | WBRNAi00073283 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00019018 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00065106 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092872 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00035805 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00053821 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr2609 | ||||||||
Expr2610 | |||||||||
Expr1021012 | |||||||||
Expr1032915 | |||||||||
Expr1157368 | |||||||||
Expr2017954 | |||||||||
Expr2036090 | |||||||||
Drives_construct | WBCnstr00000672 | ||||||||
WBCnstr00034116 | |||||||||
Construct_product | WBCnstr00034116 | ||||||||
Antibody | WBAntibody00000653 | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (142) | |||||||||
Interaction (27) | |||||||||
Map_info | Map | II | Position | 0.829738 | Error | 0.001028 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | mnDf63 | |||||||
mnDf68 | |||||||||
mnDf69 | |||||||||
Positive_clone | T22C8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | 2_point | 620 | |||||||
626 | |||||||||
Multi_point (13) | |||||||||
Pos_neg_data (17) | |||||||||
Reference (38) | |||||||||
Method | Gene |