WormBase Tree Display for Gene: WBGene00007047
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| WBGene00007047 | SMap | S_parent | Sequence | T20F10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | wts-1 | Person_evidence | WBPerson4055 | |||||
| Sequence_name | T20F10.1 | ||||||||
| Molecular_name | T20F10.1 | ||||||||
| T20F10.1.1 | |||||||||
| CE13844 | |||||||||
| Other_name | tag-181 | Person_evidence | WBPerson201 | ||||||
| CELE_T20F10.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | wts-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 13:09:06 | WBPerson1845 | Event | Created | |||
| 2 | 05 Oct 2005 17:16:52 | WBPerson2970 | Event | Acquires_merge | WBGene00011863 | ||||
| Name_change | Sequence_name | T20F10.1 | |||||||
| 3 | 01 Aug 2007 10:35:04 | WBPerson2970 | Name_change | CGC_name | wts-1 | ||||
| Other_name | tag-181 | ||||||||
| Acquires_merge | WBGene00011863 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | wts | ||||||||
| Allele (69) | |||||||||
| Strain | WBStrain00035899 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Ortholog (41) | |||||||||
| Paralog (15) | |||||||||
| Structured_description | Concise_description | wts-1 encodes a serine/threonine protein kinase orthologous to members of the NDR/LATS family of protein kinases; wts-1 is required for the integrity of the apical intestinal membrane via regulation of the localization of newly synthesized apical actins; wts-1 is also required for regulating the localization of the product of YAP-1, a Yes-associated protein (Yap) homolog, between the cytoplasm and the nucleus; wts-1 is also required for larval development; WTS-1 localizes to the subapical region of the intestine. | Paper_evidence | WBPaper00034726 | |||||
| WBPaper00035180 | |||||||||
| WBPaper00041976 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Mar 2013 00:00:00 | ||||||||
| Automated_description | Enables protein kinase activity and transcription coactivator binding activity. Involved in several processes, including apical protein localization; negative regulation of protein import into nucleus; and post-embryonic development. Located in apical plasma membrane and cytoplasm. Expressed in several structures, including excretory canal; hypodermis; intestine; spermatheca; and vulva. Human ortholog(s) of this gene implicated in colorectal cancer. Is an ortholog of human LATS1 (large tumor suppressor kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6515) | ||||
| Molecular_info | Corresponding_CDS | T20F10.1 | |||||||
| Corresponding_transcript | T20F10.1.1 | ||||||||
| Other_sequence (21) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern | Expr6722 | ||||||||
| Expr8660 | |||||||||
| Expr12814 | |||||||||
| Expr1025462 | |||||||||
| Expr1033025 | |||||||||
| Expr1157195 | |||||||||
| Expr2018086 | |||||||||
| Expr2036224 | |||||||||
| Drives_construct | WBCnstr00002402 | ||||||||
| WBCnstr00013427 | |||||||||
| WBCnstr00034026 | |||||||||
| Construct_product | WBCnstr00013427 | ||||||||
| WBCnstr00034026 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (84) | |||||||||
| Interaction (41) | |||||||||
| Map_info | Map | I | Position | 4.85706 | Error | 0.019382 | |||
| Positive | Positive_clone | T20F10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5552 | |||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | tag-181 is parsed from CGC strain VC590 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
