WormBase Tree Display for Gene: WBGene00007197

WBGene00007197 SMap: S_parent: Sequence: B0513
  Identity: Version: 2
    Name: CGC_name: prdh-1 Person_evidence: WBPerson2173
      Sequence_name: B0513.5
      Molecular_name: B0513.5a
        B0513.5a.1
        CE37309
        B0513.5b
        CE49937
        B0513.5b.1
      Other_name: prodh Paper_evidence: WBPaper00050536
        CELE_B0513.5 Accession_evidence: NDB BX284604
      Public_name: prdh-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:47 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 11 Jun 2018 11:44:56 WBPerson1983 Name_change: CGC_name: prdh-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: prdh
    Allele (134)
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (52)
    Structured_description: Automated_description: Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in mitochondrion. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in hyperprolinemia type 1 and schizophrenia 4. Is an ortholog of human PRODH (proline dehydrogenase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0060413 Homo sapiens Paper_evidence: WBPaper00047004
          Curator_confirmed: WBPerson324
          Date_last_updated: 20 Sep 2018 00:00:00
    Potential_model: DOID:0070080 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9453)
      DOID:0080542 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9453)
      DOID:9252 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9453)
    Disease_relevance: 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including PRODH (Proline dehydrogenase (oxidase) 1); the C. elegans ortholog prdh-1 knockdown phenotypes include reduced accumulation rate of newly synthesized proteins, extended life span and increased thermo-tolerance. Homo sapiens Paper_evidence: WBPaper00047004
          Accession_evidence: OMIM 611867
              239500
              600850
              606810
          Curator_confirmed: WBPerson324
          Date_last_updated: 15 Sep 2015 00:00:00
  Models_disease_in_annotation: WBDOannot00000362
  Molecular_info: Corresponding_CDS: B0513.5a
      B0513.5b
    Corresponding_CDS_history: B0513.5:wp131
    Corresponding_transcript: B0513.5a.1
      B0513.5b.1
    Other_sequence (25)
    Associated_feature: WBsf998468
      WBsf998469
      WBsf998470
      WBsf231172
  Experimental_info: RNAi_result: WBRNAi00009831 Inferred_automatically: RNAi_primary
      WBRNAi00000804 Inferred_automatically: RNAi_primary
      WBRNAi00113437 Inferred_automatically: RNAi_primary
      WBRNAi00039157 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1021073
      Expr1143312
      Expr2000233
      Expr2018453
    Drives_construct: WBCnstr00033926
    Construct_product: WBCnstr00033926
    Microarray_results (20)
    Expression_cluster: WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00038213:E.coli(LF82)_72h_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050686:glp-1(e2141)_upregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein
      WBPaper00056826:hmc_biased
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059895:wounding_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00061340:AIZ
      WBPaper00061340:M_cell
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061527:mup-2-unc-87_284
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064064:DAF-15_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064716:paraquat_downregulated
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065331:100nM-ivermectin_downregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:23_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_11
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2moreDR1350
      WBPaper00036286:Pattern_G
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037695:WC_5-day
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040876:mir-35_downregulated
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc6390]:Cluster_B
    Interaction (13)
  Map_info: Map: IV Position: 10.894
    Positive: Positive_clone: B0513 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00049828
    WBPaper00055090
    WBPaper00056909
    WBPaper00061547
    WBPaper00063976
    WBPaper00064064
    WBPaper00065331
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene