WormBase Tree Display for Gene: WBGene00007799
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| WBGene00007799 | SMap | S_parent | Sequence | C29A12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | nrx-1 | Person_evidence | WBPerson508 | |||||
| Sequence_name | C29A12.4 | ||||||||
| Molecular_name (39) | |||||||||
| Other_name | CELE_C29A12.4 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | nrx-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 18 Feb 2005 12:07:44 | WBPerson2970 | Name_change | CGC_name | nrx-1 | ||||
| 3 | 03 Mar 2005 11:35:24 | WBPerson2970 | Event | Acquires_merge | WBGene00003817 | ||||
| 4 | 21 Jan 2011 10:43:00 | WBPerson4025 | Event | Acquires_merge | WBGene00050888 | ||||
| Acquires_merge | WBGene00003817 | ||||||||
| WBGene00050888 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nrx | ||||||||
| Allele (284) | |||||||||
| Strain | WBStrain00034059 | ||||||||
| WBStrain00035064 | |||||||||
| WBStrain00036581 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00005188 | ||||||||
| 00005189 | |||||||||
| 00023933 | |||||||||
| Ortholog (45) | |||||||||
| Paralog (48) | |||||||||
| Structured_description | Concise_description | nrx-1 encodes the C. elegans ortholog of neurexins, presynaptic transmembrane neural adhesion molecules that contain extracellular laminin and EGF domains and play a critical role in synaptic development; genetic analyses suggest that nrx-1 may play a role in regulation of adult lifespan; nrx-1 expression is controlled by daf-2 and daf-16. | Paper_evidence | WBPaper00030810 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Jan 2009 00:00:00 | ||||||||
| Automated_description | Involved in negative regulation of receptor clustering. Located in presynaptic active zone. Expressed in GABAergic neurons; cholinergic neurons; nervous system; and ventral cord neurons. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Is an ortholog of human NRXN1 (neurexin 1) and NRXN3 (neurexin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060041 | Homo sapiens | Paper_evidence | WBPaper00041363 | ||||
| WBPaper00048837 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Feb 2018 00:00:00 | ||||||||
| Potential_model | DOID:0111332 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8008) | |||||
| Disease_relevance | Abnormalities in the genes encoding human Neuroligins (NLGN1,NLGN2, NLGN3, NLGN4) and Neurexins (NRXN1) are associated with Autism spectrum disorders; mutations in the elegans neurexin (nrx-1) suppress neuroligin (nlg-1) defects; nrx-1 is involved in sensory functions and adult life span and along with nrx-1 mediates a retrograde synaptic signal that inhibits neurotransmitter release at neuromuscular junctions. | Homo sapiens | Paper_evidence | WBPaper00028987 | |||||
| WBPaper00042136 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 Apr 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000165 | ||||||||
| Models_disease_asserted | WBDOannot00000476 | ||||||||
| Molecular_info | Corresponding_CDS (13) | ||||||||
| Corresponding_CDS_history | C29A12.4:wp20 | ||||||||
| C29A12.4a:wp229 | |||||||||
| C29A12.4b:wp229 | |||||||||
| C29A12.4g:wp229 | |||||||||
| C29A12.4h:wp229 | |||||||||
| Corresponding_transcript (13) | |||||||||
| Other_sequence (17) | |||||||||
| Associated_feature (30) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00041440 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00080988 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011320 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029309 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00080991 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099062 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00013755 | ||||||||
| WBCnstr00017468 | |||||||||
| WBCnstr00020790 | |||||||||
| WBCnstr00023198 | |||||||||
| WBCnstr00040466 | |||||||||
| WBCnstr00041192 | |||||||||
| Construct_product | WBCnstr00013755 | ||||||||
| WBCnstr00013756 | |||||||||
| WBCnstr00014838 | |||||||||
| WBCnstr00020409 | |||||||||
| WBCnstr00020790 | |||||||||
| WBCnstr00023198 | |||||||||
| WBCnstr00040465 | |||||||||
| WBCnstr00040466 | |||||||||
| Regulate_expr_cluster | WBPaper00053023:nrx-1(tm1961);nlg-1(ok259)_downregulated | ||||||||
| WBPaper00053023:nrx-1(tm1961);nlg-1(ok259)_upregulated | |||||||||
| WBPaper00053023:nrx-1(tm1961)_downregulated | |||||||||
| WBPaper00053023:nrx-1(tm1961)_upregulated | |||||||||
| Microarray_results (47) | |||||||||
| Expression_cluster (185) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | V | Position | 2.82231 | Error | 0.001163 | |||
| Positive | Positive_clone | C29A12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5089 | |||||||
| Pseudo_map_position | |||||||||
| Reference (40) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
