WormBase Tree Display for Gene: WBGene00007922
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| WBGene00007922 | SMap | S_parent | Sequence | C34C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pph-6 | Person_evidence | WBPerson208 | |||||
| WBPerson634 | |||||||||
| Sequence_name | C34C12.3 | ||||||||
| Molecular_name | C34C12.3 | ||||||||
| C34C12.3.1 | |||||||||
| CE31433 | |||||||||
| Other_name | CELE_C34C12.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | pph-6 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 02 Feb 2006 09:28:57 | WBPerson2970 | Name_change | CGC_name | pph-6 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pph | ||||||||
| Allele (118) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Contained_in_operon | CEOP3120 | ||||||||
| Ortholog (36) | |||||||||
| Paralog (44) | |||||||||
| Structured_description | Concise_description | pph-6 encodes the sole catalytic subunit of a PP6 protein phosphatase in the nematode genome orthologous to yeast and mammalian PP6 proteins (OMIM:612725); PPH-6 is essential for proper cortical contractility and spindle positioning in one-cell stage embryo; PPH-6 exists in a complex with SAPS-1, they mutually stabilize each other and that these two components ensure normal protein levels of their partner; PPH-6/SAPS-1 is required for maintenance of cortical patches of non-muscle myocin(NMY)-2; PPH-6/SAPS-1 contributes to cytokinesis by regulating the astral pathway which relies on contractile properties of the cortical actomyosin network during pseudocleavage stage; PPH-6/SAPS-1 promotes cortical GPR-1/2 and LIN-5; modulation of pulling forces by CSNK-1 specifically during anaphase requires PPH-6/SAPS-1. | Paper_evidence | WBPaper00035559 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 21 Jun 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein serine/threonine phosphatase activity. Involved in cortical actin cytoskeleton organization; establishment of mitotic spindle localization; and first cell cycle pseudocleavage. Located in astral microtubule and cell cortex. Is an ortholog of human PPP6C (protein phosphatase 6 catalytic subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C34C12.3 | |||||||
| Corresponding_CDS_history | C34C12.3:wp82 | ||||||||
| Corresponding_transcript | C34C12.3.1 | ||||||||
| Other_sequence (43) | |||||||||
| Associated_feature | WBsf991775 | ||||||||
| WBsf991776 | |||||||||
| WBsf991777 | |||||||||
| WBsf1014568 | |||||||||
| WBsf1014569 | |||||||||
| WBsf224614 | |||||||||
| WBsf224615 | |||||||||
| WBsf224616 | |||||||||
| WBsf224617 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr3577 | ||||||||
| Expr8879 | |||||||||
| Expr8880 | |||||||||
| Expr1012179 | |||||||||
| Expr1033436 | |||||||||
| Expr1145860 | |||||||||
| Expr2015015 | |||||||||
| Expr2033250 | |||||||||
| Drives_construct | WBCnstr00013577 | ||||||||
| WBCnstr00033379 | |||||||||
| Construct_product | WBCnstr00011501 | ||||||||
| WBCnstr00013577 | |||||||||
| WBCnstr00033379 | |||||||||
| Antibody | WBAntibody00002082 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (87) | |||||||||
| Interaction (29) | |||||||||
| Map_info | Map | III | Position | -6.76115 | Error | 0.087873 | |||
| Positive | Positive_clone | C34C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00024200 | ||||||||
| WBPaper00034581 | |||||||||
| WBPaper00035559 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00049760 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00060774 | |||||||||
| WBPaper00063976 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
