WormBase Tree Display for Gene: WBGene00008074

WBGene00008074 SMap: S_parent: Sequence: C43F9
  Identity: Version: 2
    Name: CGC_name: nkb-2 Person_evidence: WBPerson919
            WBPerson287
      Sequence_name: C43F9.6
      Molecular_name: C43F9.6
        C43F9.6.1
        CE19734
      Other_name: CELE_C43F9.6 Accession_evidence: NDB BX284604
      Public_name: nkb-2
    DB_info: Database: AceView gene 4L357
        WormQTL gene WBGene00008074
        WormFlux gene WBGene00008074
        NDB locus_tag CELE_C43F9.6
        Panther gene CAEEL|WormBase=WBGene00008074|UniProtKB=Q9XUG9
          family PTHR11523
        NCBI gene 177950
        RefSeq protein NM_069557.4
        TrEMBL UniProtAcc Q9XUG9
        UniProt_GCRP UniProtAcc Q9XUG9
        OMIM gene 182330
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Oct 2008 09:57:22 WBPerson2970 Name_change: CGC_name: nkb-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nkb
    Allele (28)
    Strain: WBStrain00031380
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (54)
    Paralog: WBGene00007646 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010117 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Human ortholog(s) of this gene implicated in several diseases, including atrophic gastritis; autoimmune gastritis; and essential hypertension. Is an ortholog of several human genes including ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); ATP1B2 (ATPase Na+/K+ transporting subunit beta 2); and ATP1B3 (ATPase Na+/K+ transporting subunit beta 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:8929 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:820)
      DOID:10825 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:804)
      DOID:0040090 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:820)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:820)
  Molecular_info: Corresponding_CDS: C43F9.6
    Corresponding_transcript: C43F9.6.1
    Other_sequence: CJC18069_1
    Associated_feature: WBsf229005
  Experimental_info: RNAi_result: WBRNAi00029767 Inferred_automatically: RNAi_primary
      WBRNAi00011889 Inferred_automatically: RNAi_primary
      WBRNAi00042391 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1010637
      Expr1146382
      Expr2014269
      Expr2032509
    Drives_construct: WBCnstr00033255
    Construct_product: WBCnstr00033255
    Microarray_results (20)
    Expression_cluster (171)
    Interaction (271)
  Map_info: Map: IV Position: 4.641 Error: 0.000196
    Positive: Positive_clone: C43F9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00043657
    WBPaper00065080
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene