WormBase Tree Display for Gene: WBGene00008082
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WBGene00008082 | SMap | S_parent | Sequence | C44B9 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | com | ||||||
Allele (101) | |||||||
Strain | WBStrain00032782 | ||||||
WBStrain00007756 | |||||||
WBStrain00007765 | |||||||
WBStrain00007807 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00061816 | ||||||
00061817 | |||||||
00061818 | |||||||
Contained_in_operon | CEOP3883 | ||||||
Ortholog (18) | |||||||
Paralog | WBGene00009770 | ||||||
Structured_description | Concise_description | com-1 encodes an ortholog of budding yeast Sae2p, Arabidopsis AtCOM1, and human RBBP8 (CTIP; OMIM:604124) and C20orf151; like its yeast ortholog, COM-1 is probably required for completing meiotic recombination; meiotic chromosomes in com-1 mutants pair normally, but form irregular chromatin aggregates instead of diakinesis bivalents; while meiotic DNA double-strand breaks (DSBs) are formed, they appear to persist or undergo improper repair, with numerous chromosomal fragments being revealed by REC-8 depletion; conversely, suppression of DSBs by a spo-11 mutation also suppresses the diakinetic com-1 phenotype, and suppression by mre-11 increases com-1 mutant fertility; despite the presence of DSBs, the recombination protein RAD-51, which is known to associate with single-stranded (ss) DNA flanking DSBs, does not localize to meiotic chromosomes in com-1 mutants; exposure of com-1 mutants to gamma-radiation, however, induces RAD-51 foci, which suggests that the failure of RAD-51 to load is specific to meiotic (SPO-11-generated) DSBs; these data suggest that COM-1 helps generate ssDNA tails upon which RAD-51 can bind, after which RAD-51 migrates to homologous DNA tracts and triggers meiotic recombination; com-1 mutants grow and live normally (possibly because of maternally contributed COM-1) but are sterile; the C-terminal-most ~100 residues of COM-1 are strongly conserved, while COM-1's N-terminal ~400 residues have low sequence complexity. | Paper_evidence | WBPaper00031197 | |||
WBPaper00031198 | |||||||
Person_evidence | WBPerson1819 | ||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 18 Nov 2007 00:00:00 | ||||||
Automated_description | Predicted to enable damaged DNA binding activity. Predicted to be involved in DNA double-strand break processing involved in repair via single-strand annealing. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Is an ortholog of human RBBP8 (RB binding protein 8, endonuclease). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0070013 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9891) | ||
Molecular_info | Corresponding_CDS | C44B9.5 | |||||
Corresponding_CDS_history | C44B9.5:wp135 | ||||||
C44B9.5:wp200 | |||||||
Corresponding_transcript | C44B9.5.1 | ||||||
Other_sequence | JI482943.1 | ||||||
CJC01556_1 | |||||||
Associated_feature | WBsf994183 | ||||||
WBsf1015872 | |||||||
WBsf225773 | |||||||
Experimental_info | RNAi_result | WBRNAi00042439 | Inferred_automatically | RNAi_primary | |||
WBRNAi00006169 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1027979 | ||||||
Expr1033510 | |||||||
Expr1146428 | |||||||
Expr2010448 | |||||||
Expr2028688 | |||||||
Microarray_results (18) | |||||||
Expression_cluster (110) | |||||||
Interaction (24) | |||||||
Map_info | Map | III | Position | 5.56963 | Error | 0.007343 | |
Positive | Positive_clone | C44B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (11) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |