WormBase Tree Display for Gene: WBGene00008140

WBGene00008140 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 3
    Name: CGC_name: xpf-1 Paper_evidence: WBPaper00024359
            WBPaper00028727
            WBPaper00043946
            WBPaper00043947
      Sequence_name: C47D12.8
      Molecular_name: C47D12.8
        C47D12.8.1
        CE24855
        C47D12.8.2
      Other_name: him-9 Person_evidence: WBPerson261
        CELE_C47D12.8 Accession_evidence: NDB BX284602
      Public_name: xpf-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 11 Oct 2013 12:53:55 WBPerson2970 Name_change: CGC_name: xpf-1
                Other_name: xpf-1 removed
        3 01 Jul 2015 11:12:28 WBPerson2970 Event: Acquires_merge: WBGene00001868
              Name_change: Other_name: him-9
      Acquires_merge: WBGene00001868
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: xpf
    Allele (192)
    Legacy_information: e1487aci : self-progeny 5% males 2% nullo-X ova. ES3 (progeny). ME3. NA1.
      See also e1487
      [C.elegansII] e1487aci : self-progeny 5% males, 2% nullo-X ova. ES3 (progeny). ME3. NA1. [Hodgkin et al. 1979]
    Strain (28)
    RNASeq_FPKM (74)
    GO_annotation (25)
    Contained_in_operon: CEOP2572
    Ortholog (38)
    Structured_description: Concise_description: xpf-1 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to Xeroderma Pigmentosum (Complementation group F; OMIM:133520); xpf-1 is a core NER (Nuclear Excision Repair) factor (other members being xpa-1, xpg-1, and ercc-1); NER factors remove UV-induced DNA damage and have been demonstrated to be required for both the global genome repair (GGR) and transcription coupled repair (TCR) pathways; XPF-1 activity is essential for the survival of germ cells and somatic tissue following UV irradiation and is necessary for germ cells and embryos to survive even relatively low doses of UV irradiation; mutations in xpf-1, as well as the other NER factors, renders animals hypersensitive to UV light; xpf-1(RNAi) animals are also hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; XPF-1 protein interacts with ERCC-1 (an ERCC1 ortholog) in yeast two-hybrid assays; xpf-1 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; xpf-1 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3. Paper_evidence: WBPaper00004805
            WBPaper00005039
            WBPaper00024359
            WBPaper00024497
            WBPaper00036260
          Person_evidence: WBPerson1684
          Curator_confirmed: WBPerson712
            WBPerson1823
            WBPerson567
          Date_last_updated: 26 Jul 2010 00:00:00
      Automated_description: Enables enzyme binding activity. Involved in DNA damage response; meiotic nuclear division; and regulation of multicellular organismal development. Predicted to be part of nucleotide-excision repair factor 1 complex. Expressed in body wall musculature; embryonic cell; germ cell; and neurons. Used to study Cockayne syndrome; Fanconi anemia; and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group Q; XFE progeroid syndrome; and polyneuropathy due to drug. Is an ortholog of human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:2962 Homo sapiens Paper_evidence: WBPaper00060873
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 May 2022 00:00:00
      DOID:13636 Homo sapiens Paper_evidence: WBPaper00060873
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 May 2022 00:00:00
      DOID:0050427 Homo sapiens Paper_evidence: WBPaper00060873
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 May 2022 00:00:00
    Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3436)
      DOID:0060590 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3436)
      DOID:0110848 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3436)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3436)
      DOID:0111093 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3436)
      DOID:14184 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3436)
      DOID:0050427 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3436)
  Models_disease_asserted: WBDOannot00001184
    WBDOannot00001185
    WBDOannot00001186
    WBDOannot00001187
  Molecular_info: Corresponding_CDS: C47D12.8
    Corresponding_transcript: C47D12.8.1
      C47D12.8.2
    Other_sequence (44)
    Associated_feature: WBsf034272
      WBsf658260
      WBsf658261
      WBsf658262
      WBsf976345
      WBsf989857
      WBsf989858
      WBsf989859
      WBsf1013293
      WBsf222179
  Experimental_info: RNAi_result: WBRNAi00062836 Inferred_automatically: RNAi_primary
      WBRNAi00042669 Inferred_automatically: RNAi_primary
      WBRNAi00062837 Inferred_automatically: RNAi_primary
      WBRNAi00036116 Inferred_automatically: RNAi_primary
      WBRNAi00012071 Inferred_automatically: RNAi_primary
      WBRNAi00106933 Inferred_automatically: RNAi_primary
      WBRNAi00061508 Inferred_automatically: RNAi_primary
      WBRNAi00111633 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1702
      Expr3076
      Expr5529
      Expr15929
      Expr1027901
      Expr1033534
      Expr1146656
      Expr2018104
      Expr2036242
    Drives_construct: WBCnstr00003346
    Regulate_expr_cluster: WBPaper00062497:xpf-1(tm2842)_downregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
    Microarray_results (22)
    Expression_cluster (88)
    SAGE_tag: SAGE:tatactggcttcaatac Strand: Sense
        Unambiguously_mapped
      SAGE:cgagaattca Strand: Sense
        Unambiguously_mapped
      SAGE:cggaagagctcagcgga Strand: Sense
        Unambiguously_mapped
      SAGE:acgagagctattttgtc Strand: Sense
        Unambiguously_mapped
      SAGE:cgagaattcaacagcga Strand: Sense
        Unambiguously_mapped
      SAGE:aatcatttct Strand: Antisense
      SAGE:acgagagcta Strand: Sense
        Unambiguously_mapped
      SAGE:atcgacgtggtcatatt Strand: Sense
        Unambiguously_mapped
      SAGE:aagggatctgttgggat Strand: Antisense
      SAGE:tatactggct Strand: Sense
        Unambiguously_mapped
    Interaction (123)
  Map_info: Map: II Position: 3.99161
    Positive: Positive_clone: C47D12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 269
      Multi_point: 55
    Pseudo_map_position
  Reference (41)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene