WormBase Tree Display for Gene: WBGene00008821

WBGene00008821 SMap: S_parent: Sequence: F14H3
  Identity: Version: 2
    Name: CGC_name: best-12 Person_evidence: WBPerson260
      Sequence_name: F14H3.2
      Molecular_name: F14H3.2
        F14H3.2.1
        CE15827
        F14H3.2.2
      Other_name: CELE_F14H3.2 Accession_evidence: NDB BX284605
      Public_name: best-12
    DB_info: Database: AceView gene 5Q531
        WormQTL gene WBGene00008821
        WormFlux gene WBGene00008821
        NDB locus_tag CELE_F14H3.2
        Panther gene CAEEL|WormBase=WBGene00008821|UniProtKB=O45363
          family PTHR10736
        NCBI gene 184489
        RefSeq protein NM_074635.3
        SwissProt UniProtAcc O45363
        UniProt_GCRP UniProtAcc O45363
        OMIM gene 607854
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 07 Feb 2012 16:30:56 WBPerson2970 Name_change: CGC_name: best-12
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: best
    Allele (79)
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (19)
    Paralog (26)
    Structured_description: Automated_description: Predicted to enable chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy and retinal degeneration (multiple). Is an ortholog of several human genes including BEST1 (bestrophin 1); BEST2 (bestrophin 2); and BEST3 (bestrophin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110396 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:4448 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:0050661 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:0050662 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
      DOID:0111569 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12703)
  Molecular_info: Corresponding_CDS: F14H3.2
    Corresponding_transcript: F14H3.2.1
      F14H3.2.2
    Associated_feature: WBsf233070
  Experimental_info: RNAi_result: WBRNAi00030969 Inferred_automatically: RNAi_primary
      WBRNAi00013321 Inferred_automatically: RNAi_primary
      WBRNAi00044653 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1023395
      Expr1148627
    Drives_construct: WBCnstr00032658
    Construct_product: WBCnstr00032658
    Microarray_results (17)
    Expression_cluster (93)
    Interaction (21)
  Map_info: Map: V Position: 9.41796
    Positive: Positive_clone: F14H3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene