WormBase Tree Display for Gene: WBGene00011261
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| WBGene00011261 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | nphp-4 | Person_evidence | WBPerson44 | |||||
| Sequence_name | R13H4.1 | ||||||||
| Molecular_name | R13H4.1 | ||||||||
| R13H4.1.1 | |||||||||
| CE38409 | |||||||||
| Other_name | nph-4 | ||||||||
| CELE_R13H4.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | nphp-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 15 Sep 2004 14:26:37 | WBPerson1971 | Name_change | CGC_name | nphp-4 | ||||
| 3 | 04 Mar 2005 10:39:00 | WBPerson2970 | Name_change | CGC_name | changed from nphp-4 to nph-4 | ||||
| 4 | 18 Jan 2011 10:01:33 | WBPerson2970 | Name_change | CGC_name | nphp-4 | ||||
| Other_name | nph-4 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nphp | ||||||||
| Allele (151) | |||||||||
| Strain | WBStrain00031067 | ||||||||
| WBStrain00031068 | |||||||||
| Component_of_genotype | WBGenotype00000132 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (38) | |||||||||
| Ortholog (65) | |||||||||
| Structured_description | Concise_description | nphp-4 encodes an ortholog of human NPHP4 (OMIM:607215, mutated injuvenile nephronophthisis and Senior-Loken syndrome-4) that is requiredfor normal chemotaxis, lifespan, and male mating behavior; NPHP-4 isexpressed in diverse neurons (amphid and phasmid sensory, URX, labial,male lumbar and cloacal ganglia, and male-specific CEM, HOB and RnB);within neurons, NPHP-4 is a ciliary protein, localized to the transistionzone at cilial bases rather than ciliary axonemes, and absent fromsomata, axons, or dendrites; NPHP-4 colocalizes with NPHP-1 and PKD-2 inmale-specific sensory cilia, and is required for the normal ciliarylocalization of NPHP-1; NPHP-4 expression requires DAF-19, and mutating anX-box in nphp-4's promoter abolishes nphp-4 expression; NPHP-4 is requiredfor NPHP-1's localization to transistion zones; morphologically, nphp-4mutant cilia are normal, indicating a function for NPHP-4 in signaltransduction. | Paper_evidence | WBPaper00024994 | |||||
| WBPaper00025076 | |||||||||
| WBPaper00025119 | |||||||||
| WBPaper00027772 | |||||||||
| WBPaper00028471 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 Jan 2011 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including determination of adult lifespan; male mating behavior; and plasma membrane bounded cell projection organization. Located in ciliary basal body; ciliary transition zone; and non-motile cilium. Expressed in cloacal ganglion; neurons; and tail ganglion. Used to study Meckel syndrome and nephronophthisis. Human ortholog(s) of this gene implicated in several diseases, including Joubert syndrome 4; Senior-Loken syndrome; and nephronophthisis 4. Is an ortholog of human NPHP4 (nephrocystin 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:12712 | Homo sapiens | Paper_evidence | WBPaper00031566 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 May 2018 00:00:00 | ||||||||
| DOID:0050778 | |||||||||
| DOID:0060340 | |||||||||
| Potential_model | DOID:1682 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | |||||
| DOID:0110999 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | ||||||
| DOID:0111115 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | ||||||
| DOID:0050576 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | ||||||
| DOID:12712 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19104) | ||||||
| Models_disease_asserted | WBDOannot00000032 | ||||||||
| WBDOannot00000123 | |||||||||
| WBDOannot00000124 | |||||||||
| WBDOannot00000136 | |||||||||
| WBDOannot00000137 | |||||||||
| WBDOannot00000138 | |||||||||
| WBDOannot00000305 | |||||||||
| WBDOannot00000306 | |||||||||
| WBDOannot00000518 | |||||||||
| WBDOannot00000615 | |||||||||
| Molecular_info | Corresponding_CDS | R13H4.1 | |||||||
| Corresponding_CDS_history | R13H4.1:wp109 | ||||||||
| R13H4.1:wp141 | |||||||||
| Corresponding_transcript | R13H4.1.1 | ||||||||
| Other_sequence | EY472394.1 | ||||||||
| EY462234.1 | |||||||||
| ACC13914_1 | |||||||||
| EY461993.1 | |||||||||
| Associated_feature | WBsf653157 | ||||||||
| WBsf669422 | |||||||||
| WBsf669423 | |||||||||
| WBsf669424 | |||||||||
| WBsf1001453 | |||||||||
| WBsf1001454 | |||||||||
| WBsf1001455 | |||||||||
| WBsf234588 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00017847 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00060981 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034929 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00060980 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051936 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051935 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (14) | |||||||||
| Drives_construct (15) | |||||||||
| Construct_product (12) | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (168) | |||||||||
| Interaction (13) | |||||||||
| Map_info | Map | V | Position | 3.42069 | Error | 0.011453 | |||
| Positive | Positive_clone | R13H4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4408 | |||||||
| 4808 | |||||||||
| 4844 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (44) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
