WormBase Tree Display for Gene: WBGene00012073

WBGene00012073 SMap: S_parent: Sequence: T27A8
  Identity: Version: 2
    Name: CGC_name: cpd-2 Person_evidence: WBPerson260
      Sequence_name: T27A8.1
      Molecular_name: T27A8.1
        T27A8.1.1
        CE35629
      Other_name: CELE_T27A8.1 Accession_evidence: NDB BX284606
      Public_name: cpd-2
    DB_info: Database: AceView gene XQ667
        WormQTL gene WBGene00012073
        WormFlux gene WBGene00012073
        NDB locus_tag CELE_T27A8.1
        Panther gene CAEEL|WormBase=WBGene00012073|UniProtKB=Q22825
          family PTHR11532
        NCBI gene 181684
        RefSeq protein NM_078224.8
        TrEMBL UniProtAcc Q22825
        UniProt_GCRP UniProtAcc Q22825
        OMIM gene 603103
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 10 Feb 2012 15:49:10 WBPerson2970 Name_change: CGC_name: cpd-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpd
    Allele (122)
    Strain: WBStrain00032993
    RNASeq_FPKM (74)
    GO_annotation: 00076550
      00076551
      00076552
      00076553
      00076554
      00076555
      00119264
      00119265
      00119266
    Ortholog (40)
    Paralog: WBGene00001189 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019074 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: T27A8.1 encodes a putative metallocarboxypeptidase orthologous to humanAEBP1 (OMIM:602981) and carboxypeptidase D, E, M, N, X2, and Zprecursors; T27A8.1 and its human orthologs, along with other proteins,comprise an M14B peptidase subfamily; T27A8.1 has no obvious function inmass RNAi assays. Paper_evidence: WBPaper00029056
          Curator_confirmed: WBPerson567
          Date_last_updated: 22 May 2007 00:00:00
      Automated_description: Predicted to enable metallocarboxypeptidase activity. Involved in regulation of muscle contraction. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency; morbid obesity; and type 2 diabetes mellitus. Is an ortholog of human CPE (carboxypeptidase E); CPM (carboxypeptidase M); and CPN1 (carboxypeptidase N subunit 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111583 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2312)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2303)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2303)
      DOID:11981 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2303)
  Molecular_info: Corresponding_CDS: T27A8.1
    Corresponding_CDS_history: T27A8.1:wp109
    Corresponding_transcript: T27A8.1.1
    Other_sequence (15)
    Associated_feature: WBsf979061
      WBsf1008412
      WBsf1008413
      WBsf1008414
      WBsf1008415
      WBsf1024704
      WBsf1024705
      WBsf236827
  Experimental_info: RNAi_result: WBRNAi00019301 Inferred_automatically: RNAi_primary
      WBRNAi00089169 Inferred_automatically: RNAi_primary
      WBRNAi00036018 Inferred_automatically: RNAi_primary
      WBRNAi00054266 Inferred_automatically: RNAi_primary
      WBRNAi00000660 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1024100
      Expr1035334
      Expr1157814
      Expr2010479
      Expr2028719
    Drives_construct: WBCnstr00030153
    Construct_product: WBCnstr00030153
    Microarray_results (19)
    Expression_cluster (145)
    Interaction: WBInteraction000236187
      WBInteraction000319942
      WBInteraction000389437
      WBInteraction000422708
      WBInteraction000474286
  Map_info: Map: X Position: 23.6879
    Positive: Positive_clone: T27A8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00058523
    WBPaper00064389
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene