WormBase Tree Display for Gene: WBGene00012137

WBGene00012137 SMap: S_parent: Sequence: T28F4
  Identity: Version: 2
    Name: CGC_name: asic-2 Person_evidence: WBPerson649
      Sequence_name: T28F4.2
      Molecular_name: T28F4.2
        T28F4.2.1
        CE06524
      Other_name: CELE_T28F4.2 Accession_evidence: NDB BX284601
      Public_name: asic-2
    DB_info: Database: AceView gene 1I59
        WormQTL gene WBGene00012137
        WormFlux gene WBGene00012137
        NDB locus_tag CELE_T28F4.2
        Panther gene CAEEL|WormBase=WBGene00012137|UniProtKB=Q22851
          family PTHR11690
        NCBI gene 189058
        RefSeq protein NM_059698.3
        SwissProt UniProtAcc Q22851
        UniProt_GCRP UniProtAcc Q22851
        OMIM gene 600228
            600760
            600761
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 01 Apr 2005 11:05:24 WBPerson2970 Name_change: CGC_name: asic-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: asic
    Allele (30)
    Strain: WBStrain00031352
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (40)
    Paralog (30)
    Structured_description: Automated_description: Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Expressed in ciliated neurons and sensory neurons. Human ortholog(s) of this gene implicated in bronchiectasis (multiple); neuroblastoma; and renal tubular transport disease (multiple). Is an ortholog of human SCNN1A (sodium channel epithelial 1 subunit alpha); SCNN1B (sodium channel epithelial 1 subunit beta); and SCNN1G (sodium channel epithelial 1 subunit gamma). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10600)
      DOID:0080527 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10599)
      DOID:0050477 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10599,HGNC:10600,HGNC:10602)
      DOID:4479 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10599,HGNC:10600,HGNC:10602)
      DOID:0080528 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10602)
      DOID:769 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10599)
  Molecular_info: Corresponding_CDS: T28F4.2
    Corresponding_transcript: T28F4.2.1
    Other_sequence: Acan_isotig17420
      CJC08786_1
    Associated_feature: WBsf656525
      WBsf656526
      WBsf656527
      WBsf984197
      WBsf984198
      WBsf1010095
  Experimental_info: RNAi_result: WBRNAi00004345 Inferred_automatically: RNAi_primary
      WBRNAi00054441 Inferred_automatically: RNAi_primary
      WBRNAi00036102 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr10143
      Expr14455
      Expr1017075
      Expr1157985
      Expr2009453
      Expr2027690
    Drives_construct: WBCnstr00030114
      WBCnstr00040884
    Construct_product: WBCnstr00030114
    Microarray_results (19)
    Expression_cluster (108)
    Interaction: WBInteraction000295447
      WBInteraction000401007
  Map_info: Map: I Position: 2.09614 Error: 0.000605
    Positive: Positive_clone: T28F4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5171
        4481
        5547
    Pseudo_map_position
  Reference: WBPaper00010498
    WBPaper00027280
    WBPaper00038491
    WBPaper00043908
    WBPaper00053550
    WBPaper00055090
    WBPaper00063946
    WBPaper00065804
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene