WormBase Tree Display for Gene: WBGene00012543
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| WBGene00012543 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | nkcc-1 | Person_evidence | WBPerson1315 | |||||
| Sequence_name | Y37A1C.1 | ||||||||
| Molecular_name (26) | |||||||||
| Other_name | CELE_Y37A1C.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | nkcc-1 | ||||||||
| DB_info | Database | AceView | gene | 4O872 | |||||
| WormQTL | gene | WBGene00012543 | |||||||
| WormFlux | gene | WBGene00012543 | |||||||
| NDB | locus_tag | CELE_Y37A1C.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00012543|UniProtKB=H8ESD5 | |||||||
| family | PTHR11827 | ||||||||
| NCBI | gene | 3565648 | |||||||
| RefSeq | protein | NM_001268859.3 | |||||||
| NM_070304.1 | |||||||||
| NM_001276883.3 | |||||||||
| NM_001268862.4 | |||||||||
| NM_001268861.4 | |||||||||
| NM_001268860.3 | |||||||||
| NM_070303.2 | |||||||||
| NM_001083255.4 | |||||||||
| TrEMBL | UniProtAcc | G5EFN5 | |||||||
| G5EFE5 | |||||||||
| L8E912 | |||||||||
| H8ESD5 | |||||||||
| G5EEQ4 | |||||||||
| H8ESD4 | |||||||||
| E9P897 | |||||||||
| E9P898 | |||||||||
| UniProt_GCRP | UniProtAcc | H8ESD5 | |||||||
| OMIM | gene | 600839 | |||||||
| 600840 | |||||||||
| 600968 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 10 Oct 2006 13:55:33 | WBPerson4025 | Event | Acquires_merge | WBGene00009928 | ||||
| 3 | 18 May 2007 11:54:59 | WBPerson2970 | Name_change | CGC_name | nkcc-1 | ||||
| Acquires_merge | WBGene00009928 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nkcc | ||||||||
| Allele (285) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (57) | |||||||||
| Paralog | WBGene00006504 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00019205 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00017350 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020207 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015131 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00019289 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | The Y37A1C.1 gene encodes a homolog of the human gene NKCC2, which when mutated leads to hypokalemicalkalosis (OMIM:241200); the Y37A1C.1A protein is predicted to be mitochondrial with 52% accuracy. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00004637 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable sodium:potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and monoatomic ion transmembrane transport. Predicted to be located in membrane. Expressed in body wall musculature; intestine; neurons; oocyte; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant nonsyndromic deafness 78; middle cerebral artery infarction; and renal tubular transport disease (multiple). Is an ortholog of human SLC12A1 (solute carrier family 12 member 1) and SLC12A2 (solute carrier family 12 member 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112159 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10911) | ||||
| DOID:0050450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10912) | ||||||
| DOID:445 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10910) | ||||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10912) | ||||||
| DOID:0110142 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10910) | ||||||
| DOID:3525 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10911) | ||||||
| Molecular_info | Corresponding_CDS | Y37A1C.1a | |||||||
| Y37A1C.1b | |||||||||
| Y37A1C.1c | |||||||||
| Y37A1C.1d | |||||||||
| Y37A1C.1e | |||||||||
| Y37A1C.1f | |||||||||
| Y37A1C.1g | |||||||||
| Y37A1C.1h | |||||||||
| Corresponding_transcript | Y37A1C.1a.1 | ||||||||
| Y37A1C.1b.1 | |||||||||
| Y37A1C.1c.1 | |||||||||
| Y37A1C.1c.2 | |||||||||
| Y37A1C.1d.1 | |||||||||
| Y37A1C.1e.1 | |||||||||
| Y37A1C.1f.1 | |||||||||
| Y37A1C.1g.1 | |||||||||
| Y37A1C.1g.2 | |||||||||
| Y37A1C.1h.1 | |||||||||
| Other_sequence (79) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00015367 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00103375 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055861 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047919 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032583 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036780 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001780 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020210 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001796 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr12193 | ||||||||
| Expr1012978 | |||||||||
| Expr1035549 | |||||||||
| Expr1159389 | |||||||||
| Expr2014271 | |||||||||
| Expr2032511 | |||||||||
| Drives_construct | WBCnstr00020170 | ||||||||
| WBCnstr00029915 | |||||||||
| Construct_product | WBCnstr00029915 | ||||||||
| Microarray_results (46) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction (34) | |||||||||
| Map_info | Map | IV | Position | 11.4715 | Error | 0.002153 | |||
| Positive | Positive_clone | Y37A1C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00039261 | |||||||||
| WBPaper00046386 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00060638 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
