WormBase Tree Display for Gene: WBGene00012857
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| WBGene00012857 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | pbo-5 | Paper_evidence | WBPaper00031426 | |||||
| Person_evidence | WBPerson655 | ||||||||
| Sequence_name | Y44A6E.1 | ||||||||
| Molecular_name | Y44A6E.1a | ||||||||
| Y44A6E.1a.1 | |||||||||
| CE32021 | |||||||||
| Y44A6E.1b | |||||||||
| CE37284 | |||||||||
| Y44A6E.1b.1 | |||||||||
| Other_name | lgc-2 | Paper_evidence | WBPaper00029376 | ||||||
| Person_evidence | WBPerson1430 | ||||||||
| CELE_Y44A6E.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | pbo-5 | ||||||||
| DB_info | Database | AceView | gene | 5V387 | |||||
| WormQTL | gene | WBGene00012857 | |||||||
| WormFlux | gene | WBGene00012857 | |||||||
| NDB | locus_tag | CELE_Y44A6E.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00012857|UniProtKB=G5ECT0 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 189903 | |||||||
| RefSeq | protein | NM_001029068.5 | |||||||
| NM_001029069.7 | |||||||||
| SwissProt | UniProtAcc | G5ECT0 | |||||||
| UniProt_GCRP | UniProtAcc | G5ECT0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 18 May 2007 16:58:23 | WBPerson2970 | Name_change | CGC_name | lgc-2 | ||||
| 3 | 01 Feb 2008 14:41:12 | WBPerson2970 | Event | Acquires_merge | WBGene00003944 | ||||
| Name_change | CGC_name | pbo-5 | |||||||
| Other_name | lgc-2 | ||||||||
| Acquires_merge | WBGene00003944 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pbo | ||||||||
| Allele (126) | |||||||||
| Legacy_information | [C.elegansII] sa242 : pBoc step of defecation motor program completely absent, other aspects of motor program and timing normal; apparently normal feeding. NA1. [JT] | ||||||||
| Strain | WBStrain00006657 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (26) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | pbo-5 encodes a proton-gated ion channel required for normal posterior body muscle contractions during defecation; PBO-5 has no obvious non-nematode orthologs, but is paralogous to PBO-6/LGC-3; PBO-5 is expressed in the most posterior bodywall muscles, and in the head neurons RIFL, RIFR, and RIS; heterologous PBO-5/PBO-6 produces strong currents in Xenopus oocytes when stimulated by pH 6.0; pbo-5 mutants are completely deficient in posterior contractions, but move normally, indicating that their defect is in defecation rather than in a more general one in posterior muscle function; pbo-5 mutants have normal PBO-4-mediated acidification pulses at the basolateral face of the posterior intestine, yet fail to contract. | Paper_evidence | WBPaper00001256 | |||||
| WBPaper00031426 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 05 Feb 2008 00:00:00 | ||||||||
| Automated_description | Enables extracellular ligand-gated monoatomic ion channel activity. Involved in defecation; lipid transport involved in lipid storage; and positive regulation of multicellular organismal process. Predicted to be located in neuron projection and synapse. Expressed in RIFL; RIFR; RIS; and body wall musculature. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y44A6E.1a | |||||||
| Y44A6E.1b | |||||||||
| Corresponding_CDS_history | Y44A6E.1:wp87 | ||||||||
| Corresponding_transcript | Y44A6E.1a.1 | ||||||||
| Y44A6E.1b.1 | |||||||||
| Other_sequence | Tcol_isotig20449 | ||||||||
| Oden_isotig15669 | |||||||||
| Associated_feature | WBsf647774 | ||||||||
| WBsf662288 | |||||||||
| WBsf662289 | |||||||||
| WBsf1003664 | |||||||||
| WBsf1003665 | |||||||||
| WBsf1003666 | |||||||||
| WBsf1022027 | |||||||||
| WBsf1022028 | |||||||||
| WBsf1022029 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00066374 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00056554 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9628 | ||||||||
| Expr1012602 | |||||||||
| Expr1160028 | |||||||||
| Expr2014762 | |||||||||
| Expr2032996 | |||||||||
| Drives_construct | WBCnstr00014189 | ||||||||
| Construct_product | WBCnstr00042604 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (104) | |||||||||
| Interaction | WBInteraction000554935 | ||||||||
| WBInteraction000556792 | |||||||||
| Map_info | Map | V | Position | 25.8116 | |||||
| Positive | Positive_clone | Y44A6E | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
