WormBase Tree Display for Gene: WBGene00013095
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| WBGene00013095 | SMap | S_parent | Sequence | Y51H1A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ing-3 | Person_evidence | WBPerson399 | |||||
| Sequence_name | Y51H1A.4 | ||||||||
| Molecular_name | Y51H1A.4 | ||||||||
| Y51H1A.4.1 | |||||||||
| CE20286 | |||||||||
| Other_name | CELE_Y51H1A.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | ing-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 06 Mar 2007 15:41:57 | WBPerson2970 | Name_change | CGC_name | ing-3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ing | ||||||||
| Allele (230) | |||||||||
| Strain | WBStrain00032576 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00103596 | ||||||||
| 00103597 | |||||||||
| 00103598 | |||||||||
| 00103599 | |||||||||
| 00103600 | |||||||||
| 00103601 | |||||||||
| 00103602 | |||||||||
| Contained_in_operon | CEOP2620 | ||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00021545 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00020287 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ing-3 encodes a plant homeodomain-containing protein closely related to human ING3 (Inhibitor of Growth 3, OMIM:607493), mutations in which have been associated with head and neck cancers; genetic analysis indicates that, in the germline, ING-3 functions with CEP-1/p53 to effect germ cell apoptosis in response to gamma irradiation; in addition, ING-3 activity also appears to be required for fully normal locomotion; ING-3 is widely expressed from embryogenesis through adulthood and co-localizes with chromatin in both germ cells and somatic tissues. | Paper_evidence | WBPaper00032356 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Nov 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Expressed in several structures, including hypodermis; intestine; pharynx; spermatheca; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma. Is an ortholog of human ING3 (inhibitor of growth family member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00032356 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 22 May 2018 00:00:00 | ||||||||
| Potential_model | DOID:5520 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6062) | |||||
| DOID:1749 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6062) | ||||||
| Models_disease_asserted | WBDOannot00000525 | ||||||||
| Molecular_info | Corresponding_CDS | Y51H1A.4 | |||||||
| Corresponding_transcript | Y51H1A.4.1 | ||||||||
| Other_sequence (56) | |||||||||
| Associated_feature | WBsf222404 | ||||||||
| WBsf222405 | |||||||||
| WBsf222406 | |||||||||
| Transcription_factor | WBTranscriptionFactor000700 | ||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr8385 | ||||||||
| Expr8386 | |||||||||
| Expr8387 | |||||||||
| Expr1027326 | |||||||||
| Expr1035811 | |||||||||
| Expr1160606 | |||||||||
| Expr2012743 | |||||||||
| Expr2030980 | |||||||||
| Drives_construct | WBCnstr00013293 | ||||||||
| WBCnstr00013294 | |||||||||
| Antibody | WBAntibody00001483 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction (65) | |||||||||
| Map_info | Map | II | Position | 20.6105 | Error | 0.150247 | |||
| Positive | Positive_clone | Y51H1A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
