WormBase Tree Display for Gene: WBGene00013695
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| WBGene00013695 | SMap | S_parent | Sequence | Y106G6A | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | ||||||||
| Name | CGC_name | epg-8 | Paper_evidence | WBPaper00037833 | ||||||
| Person_evidence | WBPerson716 | |||||||||
| Sequence_name | Y106G6A.2 | |||||||||
| Molecular_name | Y106G6A.2a | |||||||||
| Y106G6A.2a.1 | ||||||||||
| CE30567 | ||||||||||
| Y106G6A.2c | ||||||||||
| CE47002 | ||||||||||
| Y106G6A.2d | ||||||||||
| CE47053 | ||||||||||
| Y106G6A.2b | ||||||||||
| Y106G6A.2c.1 | ||||||||||
| Y106G6A.2d.1 | ||||||||||
| Other_name | CELE_Y106G6A.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | epg-8 | |||||||||
| DB_info | Database (11) | |||||||||
| Species | Caenorhabditis elegans | |||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | |||
| 2 | 20 Aug 2004 17:09:32 | WBPerson1983 | Event | Changed_class | CDS | Transcript | ||||
| 3 | 05 Apr 2011 16:09:18 | WBPerson2970 | Name_change | CGC_name | epg-8 | |||||
| Status | Live | |||||||||
| Gene_info | Biotype | SO:0001217 | ||||||||
| Gene_class | epg | |||||||||
| Allele (26) | ||||||||||
| Strain | WBStrain00032632 | |||||||||
| WBStrain00008603 | ||||||||||
| RNASeq_FPKM (74) | ||||||||||
| GO_annotation (13) | ||||||||||
| Ortholog (22) | ||||||||||
| Structured_description | Concise_description | epg-8 encodes a coiled-coil domain protein that is conserved amongst nematodes; EPG-8 plays an essential role in autophagy, specifically in regulating the degradation of autophagic substrates as well as the normal levels and localization of LGG-1, the C. elegans Atg8 homolog; EPG-8 thus plays a role in regulating the survival of C. elegans under conditions of nutrient starvation; EPG-8 physically interacts with BEC-1, the C. elegans Beclin 1 homlog; an EGP-8 reporter fusion is widely expressed from embryogenesis through adulthood and localizes diffusely to the cytoplasm; based upon its physical interactions and biological role in C. elegans autophagy, epg-8 may be the functional homolog of budding yeast Atg14. | Paper_evidence | WBPaper00037833 | ||||||
| Curator_confirmed | WBPerson1843 | |||||||||
| Date_last_updated | 01 Apr 2011 00:00:00 | |||||||||
| Automated_description | Involved in macroautophagy; positive regulation of autophagy; and positive regulation of embryonic development. Located in cytoplasm. Expressed in neurons and pharyngeal muscle cell. | Paper_evidence | WBPaper00065943 | |||||||
| Curator_confirmed | WBPerson324 | |||||||||
| WBPerson37462 | ||||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | |||||||||
| Modifies_disease | DOID:10652 | |||||||||
| Modifies_disease_in_annotation | WBDOannot00001361 | |||||||||
| Molecular_info | Corresponding_CDS | Y106G6A.2a | ||||||||
| Y106G6A.2c | ||||||||||
| Y106G6A.2d | ||||||||||
| Corresponding_CDS_history | Y106G6A.2:wp77 | |||||||||
| Y106G6A.2b:wp130 | ||||||||||
| Corresponding_transcript | Y106G6A.2b | |||||||||
| Y106G6A.2a.1 | ||||||||||
| Y106G6A.2c.1 | ||||||||||
| Y106G6A.2d.1 | ||||||||||
| Other_sequence | CBC09731_1 | |||||||||
| CBC09891_1 | ||||||||||
| CBC13765_1 | ||||||||||
| Associated_feature | WBsf649530 | |||||||||
| WBsf649531 | ||||||||||
| WBsf664803 | ||||||||||
| WBsf664804 | ||||||||||
| WBsf664805 | ||||||||||
| WBsf220164 | ||||||||||
| Experimental_info | RNAi_result (16) | |||||||||
| Expr_pattern | Expr9166 | |||||||||
| Expr1021170 | ||||||||||
| Expr1036124 | ||||||||||
| Expr1158786 | ||||||||||
| Expr2011347 | ||||||||||
| Expr2029583 | ||||||||||
| Drives_construct | WBCnstr00007933 | |||||||||
| WBCnstr00013762 | ||||||||||
| WBCnstr00029561 | ||||||||||
| Construct_product | WBCnstr00013762 | |||||||||
| WBCnstr00029561 | ||||||||||
| Microarray_results (32) | ||||||||||
| Expression_cluster (113) | ||||||||||
| Interaction (11) | ||||||||||
| Map_info | Map | I | Position | 4.0707 | Error | 0.008 | ||||
| Positive | Positive_clone | Y106G6A | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Pseudo_map_position | ||||||||||
| Reference (16) | ||||||||||
| Remark | .2b isoform changed from CDS to non-coding transcript, 2a isoform is still a CDS | Curator_confirmed | WBPerson1971 | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||||
| Method | Gene |
