WormBase Tree Display for Gene: WBGene00015184
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WBGene00015184 | SMap | S_parent | Sequence | B0432 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | djr-1.1 | Person_evidence | WBPerson50 | |||||
Sequence_name | B0432.2 | ||||||||
Molecular_name | B0432.2 | ||||||||
B0432.2.1 | |||||||||
CE07740 | |||||||||
Other_name | CELE_B0432.2 | Accession_evidence | NDB | BX284602 | |||||
Public_name | djr-1.1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:30:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 07 Sep 2006 09:01:01 | WBPerson2970 | Name_change | CGC_name | djr-1.1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | djr | ||||||||
Allele (40) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (25) | |||||||||
Contained_in_operon | CEOP2024 | ||||||||
Ortholog (38) | |||||||||
Paralog | WBGene00016789 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | djr-1.1 encodes a glyoxylase orthologous to human DJ-1 (OMIM:602533, mutated in early-onset Parkinson disease); DJR-1.1 is required for resistance to rotenone, a mitochondrial complex I inhibitor that mimics Parkinson disease (PD); djr-1.1(RNAi) animals are partly rescued from PD-like sensitivity by D-beta-hydroxybutyrate or tauroursodeoxycholic acid, and fully rescued by both; by orthology with DJ-1, DJR-1.1 may promote stability of the transcription factors SKN-1 or SKNR-1 (homologs of mammalian NFE2L2); DJR-1.1 is expressed primarily in the intestine and localizes to the nucleus and the cytoplasm. | Paper_evidence | WBPaper00026906 | |||||
WBPaper00028772 | |||||||||
WBPaper00041086 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 01 May 2013 00:00:00 | ||||||||
Automated_description | Predicted to enable glyoxalase III activity. Involved in several processes, including cellular aldehyde metabolic process; cellular response to aldehyde; and monocarboxylic acid biosynthetic process. Located in cytoplasm and nucleus. Expressed in intestine. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease 7; Parkinsonism; and middle cerebral artery infarction. Is an ortholog of human PARK7 (Parkinsonism associated deglycase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00041086 | ||||
Accession_evidence | OMIM | 606324 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 28 May 2013 00:00:00 | ||||||||
Potential_model | DOID:0060370 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16369) | |||||
DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16369) | ||||||
DOID:0080855 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16369) | ||||||
DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16369) | ||||||
DOID:3525 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16369) | ||||||
Disease_relevance | Mutations in human Park7, also known as DJ1 (orthologous to elegans djr-1.1 and djr-1.2), are associated with autosomal recessive early-onset Parkinson disease; human and worm DJ1 genes are glyoxylases, and protect neurons from reactive carbonyl species like glyoxal and methylglyoxal; studies in worms indicate that the isoforms, djr-1.1 and djr-1.2, are required for viability and protection against glyoxal-induced degeneration of dopaminergic neurons; djr-1.2 is induced under metabolic dormant states (like the dauer state in worms) induced by conditions like starvation, and is regulated by the daf-16/FoxO transcription factor, a major downstream target of the insulin-like growth factor (IGF-1) signaling pathway. | Homo sapiens | Paper_evidence | WBPaper00041086 | |||||
Accession_evidence | OMIM | 602533 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 28 May 2013 00:00:00 | ||||||||
Models_disease_in_annotation | WBDOannot00000190 | ||||||||
Molecular_info | Corresponding_CDS | B0432.2 | |||||||
Corresponding_transcript | B0432.2.1 | ||||||||
Other_sequence (68) | |||||||||
Associated_feature | WBsf657259 | ||||||||
WBsf986372 | |||||||||
WBsf1011372 | |||||||||
WBsf220741 | |||||||||
WBsf220742 | |||||||||
Experimental_info | RNAi_result | WBRNAi00098091 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098087 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00028144 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00039057 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098092 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098089 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00076056 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098090 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00009775 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr10048 | ||||||||
Expr12289 | |||||||||
Expr1026891 | |||||||||
Expr1036502 | |||||||||
Expr1143219 | |||||||||
Expr2010935 | |||||||||
Expr2029174 | |||||||||
Drives_construct | WBCnstr00015021 | ||||||||
WBCnstr00017680 | |||||||||
WBCnstr00029022 | |||||||||
Construct_product | WBCnstr00015021 | ||||||||
WBCnstr00017680 | |||||||||
WBCnstr00029022 | |||||||||
Microarray_results (19) | |||||||||
Expression_cluster (84) | |||||||||
Interaction (22) | |||||||||
WBProcess | WBbiopr:00000039 | ||||||||
WBbiopr:00000096 | |||||||||
Map_info | Map | II | Position | -15.6463 | Error | 0.002029 | |||
Positive | Positive_clone | B0432 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (19) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |