WormBase Tree Display for Gene: WBGene00015418

WBGene00015418 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 3
    Name: CGC_name: pac-1 Person_evidence: WBPerson6440
            WBPerson440
      Sequence_name: C04D8.1
      Molecular_name (18)
      Other_name: CEGAP Accession_evidence: EMBL U02289
        CELE_C04D8.1 Accession_evidence: NDB BX284603
      Public_name: pac-1
    DB_info: Database: AceView gene 3J607
        WormQTL gene WBGene00015418
        WormFlux gene WBGene00015418
        NDB locus_tag CELE_C04D8.1
        Panther gene CAEEL|WormBase=WBGene00015418|UniProtKB=P34288
          family PTHR23176
        NCBI gene 176201
        RefSeq protein NM_001136361.5
            NM_001306726.3
            NM_001306727.4
            NM_001306725.3
            NM_066476.7
            NM_001306728.4
        SwissProt UniProtAcc P34288
        TrEMBL UniProtAcc U4PM34
            U4PRC7
            U4PBN0
            U4PBA1
        UniProt_GCRP UniProtAcc P34288
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 07 Feb 2008 17:23:14 WBPerson2970 Name_change: CGC_name: pac-1
        3 03 Nov 2008 13:41:14 WBPerson1849 Event: Acquires_merge: WBGene00018372
      Acquires_merge: WBGene00018372
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pac
    Allele (340)
    Strain: WBStrain00032310
      WBStrain00007530
      WBStrain00007531
    RNASeq_FPKM (74)
    GO_annotation (18)
    Contained_in_operon: CEOP3814
    Ortholog: WBGene00061815 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00037598 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            Inparanoid_8
            WormBase-Compara
      WBGene00156279 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00120244 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      WBGene00222208 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g6064 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g840 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g6403 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g12924 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g12925 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g22435 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g17627 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g3519 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g4396 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g877 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g20719 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00336.g9391 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-pac-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold571.g4256 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00872.g16321 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_15070 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_010142 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04680 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_30078700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g8415 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00183489 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00245991 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00106877 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00292860 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000000957 Saccharomyces cerevisiae From_analysis: OrthoInspector
            Panther
      FB:FBgn0031118 Drosophila melanogaster From_analysis: OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-030131-4944 Danio rerio From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-081031-78 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-121019-1 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-090918-5 Danio rerio From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      HGNC:29293 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
      MGI:3697726 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:1918685 Mus musculus From_analysis: OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:1309742 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            SonicParanoid
      RGD:1311028 Rattus norvegicus From_analysis: OrthoFinder
            OrthoInspector
            SonicParanoid
    Paralog: WBGene00008006 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: pac-1 encodes a RhoGAP (Rho guanosine triphosphatase (GTPase) activating protein); in the embryo, PAC-1 is essential for establishment of radial (inner-outer) asymmetry and specifically, for differential localization of PAR-6, PAR-3, and PKC-3 to outer somatic cell surfaces devoid of cell-cell contacts; in regulating PAR protein localization, PAC-1 appears to act by spatially regulating activity of the CDC-42 Rho GTPase which can bind PAR-6 and is required, genetically, for PAR-6 localization to the outer cell surface; a PAC-1::GFP fusion protein expressed in the early embryo and in cultured embryos localizes to points of cell-cell contact. Paper_evidence: WBPaper00031968
          Curator_confirmed: WBPerson1843
          Date_last_updated: 30 Jun 2008 00:00:00
      Automated_description: Enables GTPase activator activity. Involved in Rho protein signal transduction; protein localization; and regulation of gastrulation. Located in cell junction. Expressed in anus; epithelial cell; hypodermis; pharynx; and pm7. Is an ortholog of human ARHGAP23 (Rho GTPase activating protein 23). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C04D8.1a
      C04D8.1b
      C04D8.1d
      C04D8.1e
      C04D8.1f
      C04D8.1g
    Corresponding_CDS_history: C04D8.1:wp92
      C04D8.1a:wp196
      C04D8.1c:wp275
    Corresponding_transcript: C04D8.1a.1
      C04D8.1b.1
      C04D8.1d.1
      C04D8.1e.1
      C04D8.1f.1
      C04D8.1g.1
    Other_sequence (24)
    Associated_feature (62)
  Experimental_info: RNAi_result: WBRNAi00010104 Inferred_automatically: RNAi_primary
      WBRNAi00039589 Inferred_automatically: RNAi_primary
      WBRNAi00058797 Inferred_automatically: RNAi_primary
      WBRNAi00111060 Inferred_automatically: RNAi_primary
      WBRNAi00021621 Inferred_automatically: RNAi_primary
      WBRNAi00005915 Inferred_automatically: RNAi_primary
      WBRNAi00005216 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr68
      Expr2035
      Expr8161
      Expr12368
      Expr13517
      Expr1016440
      Expr1036597
      Expr1143693
      Expr2014677
      Expr2032910
    Drives_construct: WBCnstr00020487
      WBCnstr00020494
      WBCnstr00028863
    Construct_product (16)
    Microarray_results (39)
    Expression_cluster (124)
    Interaction (75)
  Map_info: Map: III Position: -0.25513 Error: 0.000591
    Positive: Positive_clone: C04D8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene