WormBase Tree Display for Gene: WBGene00015508
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| WBGene00015508 | SMap | S_parent | Sequence | C06A6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | mvb-12 | Person_evidence | WBPerson3188 | |||||
| WBPerson1816 | |||||||||
| Sequence_name | C06A6.3 | ||||||||
| Molecular_name | C06A6.3 | ||||||||
| C06A6.3.1 | |||||||||
| CE03941 | |||||||||
| Other_name | CELE_C06A6.3 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | mvb-12 | ||||||||
| DB_info | Database | AceView | gene | 4I599 | |||||
| WormQTL | gene | WBGene00015508 | |||||||
| WormFlux | gene | WBGene00015508 | |||||||
| NDB | locus_tag | CELE_C06A6.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00015508|UniProtKB=Q17687 | |||||||
| family | PTHR31612 | ||||||||
| NCBI | gene | 182286 | |||||||
| RefSeq | protein | NM_068901.8 | |||||||
| TREEFAM | TREEFAM_ID | TF314477 | |||||||
| TrEMBL | UniProtAcc | Q17687 | |||||||
| UniProt_GCRP | UniProtAcc | Q17687 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 10 Sep 2007 09:52:01 | WBPerson2970 | Name_change | CGC_name | mvb-1 | ||||
| 3 | 30 Oct 2007 09:56:16 | WBPerson2970 | Name_change | CGC_name | Changed from mvb-1 to mvb-12 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mvb | ||||||||
| Allele (26) | |||||||||
| Strain | WBStrain00033189 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | mvb-12 encodes a protein containing a domain of unknown function (DUF2464) that is the metazoan homolog of Saccharomyces cerevisiae Mvb12p, a member of the endosomal sorting ESCRT-I complex that functions in endosomal sorting of mono-ubiquitinated membrane proteins; in C. elegans, MVB-12 is a non-essential component of the ESCRT-I complex (essential members are VPS-28, VPS-37, and TSG-101) that affects the rate at which cell surface receptors are degraded and hence, the rate at which their activity is downregulated; an MVB-12::GFP fusion protein localizes to the cytosol and to endosomal membranes. | Paper_evidence | WBPaper00031035 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Jul 2010 00:00:00 | ||||||||
| Automated_description | Involved in endosome to lysosome transport via multivesicular body sorting pathway and receptor catabolic process. Located in cytosol and endosome membrane. Part of ESCRT I complex. Expressed in amphid neurons; hypodermis; intestine; and pm7. Is an ortholog of human MVB12B (multivesicular body subunit 12B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C06A6.3 | |||||||
| Corresponding_transcript | C06A6.3.1 | ||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf646117 | ||||||||
| WBsf659835 | |||||||||
| WBsf660335 | |||||||||
| WBsf228582 | |||||||||
| WBsf228583 | |||||||||
| WBsf228584 | |||||||||
| WBsf228585 | |||||||||
| WBsf228586 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00077251 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00077250 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039830 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077255 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028539 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr11311 | ||||||||
| Expr1027479 | |||||||||
| Expr1036636 | |||||||||
| Expr1143910 | |||||||||
| Expr2013835 | |||||||||
| Expr2032075 | |||||||||
| Drives_construct | WBCnstr00018761 | ||||||||
| WBCnstr00037996 | |||||||||
| Construct_product | WBCnstr00000921 | ||||||||
| WBCnstr00019278 | |||||||||
| WBCnstr00037996 | |||||||||
| Antibody | WBAntibody00001306 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (81) | |||||||||
| Interaction | WBInteraction000391829 | ||||||||
| WBInteraction000522625 | |||||||||
| WBInteraction000522626 | |||||||||
| WBInteraction000522627 | |||||||||
| WBInteraction000559053 | |||||||||
| WBInteraction000583919 | |||||||||
| WBInteraction000584464 | |||||||||
| Map_info | Map | IV | Position | 3.49157 | Error | 0.000495 | |||
| Positive | Positive_clone | C06A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031035 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00044445 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00059054 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Gene was previously incorrectly named mvb-1 | Curator_confirmed | WBPerson2970 | |||||||
| Method | Gene |
