WormBase Tree Display for Gene: WBGene00015776

WBGene00015776 SMap: S_parent: Sequence: C14F5
  Identity: Version: 2
    Name: CGC_name: dct-1 Paper_evidence: WBPaper00031095
          Person_evidence: WBPerson1157
      Sequence_name: C14F5.1
      Molecular_name: C14F5.1a
        C14F5.1a.1
        CE47388
        C14F5.1b
        CE47263
        C14F5.1b.1
      Other_name: ceBNIP3 Paper_evidence: WBPaper00003274
        CELE_C14F5.1 Accession_evidence: NDB BX284606
      Public_name: dct-1
    DB_info: Database: AceView gene XI573
        WormQTL gene WBGene00015776
        WormFlux gene WBGene00015776
        NDB locus_tag CELE_C14F5.1
        Panther gene CAEEL|WormBase=WBGene00015776|UniProtKB=Q09969
          family PTHR15186
        NCBI gene 181053
        RefSeq protein NM_076938.7
            NM_076939.5
        SwissProt UniProtAcc Q09969
        TREEFAM TREEFAM_ID TF315424
        UniProt_GCRP UniProtAcc Q09969
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 08 Nov 2007 16:33:50 WBPerson2970 Name_change: CGC_name: dct-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dct
    Allele (40)
    Possibly_affected_by: WBVar02158488
      WBVar02158489
    Strain: WBStrain00051768
      WBStrain00051773
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (35)
    Structured_description: Concise_description: dct-1 encodes a protein with similarity to the mammalian BNIP3 proteins that interact with Bcl-2 and the Adenovirus E1B 19kDa protein and that have been shown to have pro-apoptotic activity; loss of dct-1 activity via RNAi in daf-2 mutants and in gld-1; daf-2 doubly mutant animals indicates that dct-1 can function to regulate both lifespan and tumor cell proliferation; when expressed in mammalian cells, DCT-1 can: 1) induce delayed apoptosis and increase apoptosis when coexpressed with CED-3 (perhaps by increasing proteolyic processing of CED-3), 2) physically interact with CED-9 or the CED-3 prodomain when coexpressed, and 3) physically interact with both CED-9 and CED-3 when all three are coexpressed; chromatin immunoprecipitation experiments have demonstrated that the dct-1 promoter is bound in vivo by the forkhead transcription factor DAF-16; expression of DCT-1 in mammalian cells suggests that, like its mammalian orthologs, DCT-1 localizes to mitochondria via a predicted C-terminal transmembrane domain. Paper_evidence: WBPaper00003274
            WBPaper00004430
            WBPaper00027009
            WBPaper00031095
          Curator_confirmed: WBPerson1843
          Date_last_updated: 07 Apr 2008 00:00:00
      Automated_description: Enables protease binding activity and protein homodimerization activity. Involved in apoptotic process; determination of adult lifespan; and regulation of cell cycle. Located in mitochondrial outer membrane and protein-containing complex. Expressed in body wall musculature; intestine; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in ductal carcinoma in situ and perinatal necrotizing enterocolitis. Is an ortholog of human BNIP3 (BCL2 interacting protein 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1084)
      DOID:8677 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1084)
  Molecular_info: Corresponding_CDS: C14F5.1a
      C14F5.1b
    Corresponding_CDS_history: C14F5.1a:wp230
    Corresponding_transcript: C14F5.1a.1
      C14F5.1b.1
    Other_sequence (28)
    Associated_feature: WBsf982202
      WBsf1005993
      WBsf1005994
      WBsf1023333
      WBsf235995
  Experimental_info: RNAi_result: WBRNAi00010765 Inferred_automatically: RNAi_primary
      WBRNAi00040562 Inferred_automatically: RNAi_primary
      WBRNAi00027882 Inferred_automatically: RNAi_primary
      WBRNAi00113853 Inferred_automatically: RNAi_primary
      WBRNAi00112226 Inferred_automatically: RNAi_primary
      WBRNAi00113608 Inferred_automatically: RNAi_primary
      WBRNAi00114393 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr12538
      Expr1015796
      Expr1036748
      Expr1144617
      Expr2010818
      Expr2029055
    Drives_construct: WBCnstr00021484
      WBCnstr00028577
    Construct_product: WBCnstr00021484
      WBCnstr00028577
    Microarray_results (25)
    Expression_cluster (220)
    Interaction (44)
  Map_info: Map: X Position: -0.839041
    Positive: Positive_clone: C14F5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (28)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene