WormBase Tree Display for Gene: WBGene00016045
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| WBGene00016045 | SMap | S_parent | Sequence | C24B5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | spas-1 | Person_evidence | WBPerson4034 | |||||
| Sequence_name | C24B5.2 | ||||||||
| Molecular_name | C24B5.2a | ||||||||
| C24B5.2a.1 | |||||||||
| CE30731 | |||||||||
| C24B5.2c | |||||||||
| CE20522 | |||||||||
| C24B5.2b | |||||||||
| C24B5.2c.1 | |||||||||
| Other_name | C. elegans spastin | Paper_evidence | WBPaper00046405 | ||||||
| CELE_C24B5.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | spas-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 19 Dec 2005 12:03:03 | WBPerson2970 | Name_change | CGC_name | spas-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spas | ||||||||
| Allele (41) | |||||||||
| Strain | WBStrain00032109 | ||||||||
| WBStrain00007567 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (42) | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00003183 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00010047 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00011175 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00017981 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00021334 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00010557 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | spas-1 is an ortholog of human SPAST (spastin); spas-1 is involved in microtubule depolymerization, microtubule severing, oogenesis, protein homooligomerization and vulval development; spas-1 exhibits microtubule binding activity and microtubule-severing ATPase activity; epidermal expression of SPAS-1 triggers mild effects on embryonic elongation, which are dramatically enhanced by let-502 weak loss of function; spas-1 is expressed throughout the body including the gonad, intestine, and the vulva; spas-1 is localized to the cytoskeleton and the perinuclear region of cytoplasm. | Paper_evidence | WBPaper00029440 | |||||
| WBPaper00048849 | |||||||||
| Person_evidence | WBPerson1677 | ||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 Feb 2016 00:00:00 | ||||||||
| Automated_description | Enables several functions, including ATP binding activity; ATP hydrolysis activity; and microtubule severing ATPase activity. Involved in several processes, including microtubule cytoskeleton organization; positive regulation of microtubule depolymerization; and vulval development. Located in microtubule cytoskeleton; perinuclear region of cytoplasm; and protein-containing complex. Expressed in several structures, including intestine; mechanosensory neurons; somatic nervous system; tail ganglion; and vulva. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Is an ortholog of human SPAST (spastin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:2476 | Homo sapiens | Paper_evidence | WBPaper00029440 | ||||
| Accession_evidence | OMIM | 182601 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 Feb 2013 00:00:00 | ||||||||
| Potential_model | DOID:0110792 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11233) | |||||
| Disease_relevance | Mutations in the human ortholog of elegans spas-1, Spastin, are associated with Spastic paraplegia; studies in C. elegans identify the molecular mechanisms by which elegans spas-1 plays a role in microtubule dynamics, specifically in microtubule severing; overexpression of elegans SPAS-1 in cell culture induces the microtubule network to disintegrate, and this effect is blocked by spas-1 mutations orthologous to human disease-causing alleles; the microtubule binding domain of spas-1 allows enrichment of spas-1 to microtubules. | Homo sapiens | Paper_evidence | WBPaper00034751 | |||||
| WBPaper00029440 | |||||||||
| WBPaper00041067 | |||||||||
| Accession_evidence | OMIM | 182601 | |||||||
| 604277 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 Feb 2013 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000106 | ||||||||
| Molecular_info | Corresponding_CDS | C24B5.2a | |||||||
| C24B5.2c | |||||||||
| Corresponding_CDS_history | C24B5.2b:wp252 | ||||||||
| Corresponding_transcript | C24B5.2b | ||||||||
| C24B5.2a.1 | |||||||||
| C24B5.2c.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf655106 | ||||||||
| WBsf232222 | |||||||||
| WBsf232223 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00029133 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00041067 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007931 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011087 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4712 | ||||||||
| Expr4713 | |||||||||
| Expr4714 | |||||||||
| Expr13319 | |||||||||
| Expr1013196 | |||||||||
| Expr1036855 | |||||||||
| Expr1145101 | |||||||||
| Expr2016016 | |||||||||
| Expr2034251 | |||||||||
| Drives_construct | WBCnstr00039095 | ||||||||
| Construct_product | WBCnstr00021426 | ||||||||
| Antibody | WBAntibody00001257 | ||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction (34) | |||||||||
| Map_info | Map | V | Position | 1.94916 | Error | 0.000152 | |||
| Positive | Positive_clone | C24B5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5651 | |||||||
| 5601 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
