WormBase Tree Display for Gene: WBGene00016896
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| WBGene00016896 | SMap | S_parent | Sequence | C53B7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | nep-4 | Person_evidence | WBPerson260 | |||||
| Sequence_name | C53B7.7 | ||||||||
| Molecular_name | C53B7.7 | ||||||||
| C53B7.7.1 | |||||||||
| CE35438 | |||||||||
| Other_name | CELE_C53B7.7 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | nep-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 10 Feb 2012 15:49:10 | WBPerson2970 | Name_change | CGC_name | nep-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nep | ||||||||
| Allele (37) | |||||||||
| Strain | WBStrain00052097 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00034206 | ||||||||
| 00034207 | |||||||||
| 00034208 | |||||||||
| 00122399 | |||||||||
| 00122400 | |||||||||
| 00122401 | |||||||||
| Ortholog (76) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | C53B7.7 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C53B7.7 has no clear orthologs in other organisms. | Paper_evidence | WBPaper00004584 | |||||
| WBPaper00013276 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Is an ortholog of human ECEL1 (endothelin converting enzyme like 1) and KEL (Kell metallo-endopeptidase (Kell blood group)). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111594 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3147) | ||||
| Molecular_info | Corresponding_CDS | C53B7.7 | |||||||
| Corresponding_CDS_history | C53B7.7:wp107 | ||||||||
| Corresponding_transcript | C53B7.7.1 | ||||||||
| Associated_feature | WBsf237525 | ||||||||
| WBsf237526 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00089018 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00030109 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043083 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012352 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1010212 | ||||||||
| Expr1147046 | |||||||||
| Expr2032213 | |||||||||
| Drives_construct | WBCnstr00027719 | ||||||||
| Construct_product | WBCnstr00027719 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (46) | |||||||||
| Map_info | Map | X | Position | -2.32338 | |||||
| Positive | Positive_clone | C53B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00053154 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
