WormBase Tree Display for Gene: WBGene00017472
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| WBGene00017472 | SMap | S_parent | Sequence | F14H12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cst-1 | Person_evidence | WBPerson1787 | |||||
| Sequence_name | F14H12.4 | ||||||||
| Molecular_name | F14H12.4a | ||||||||
| F14H12.4a.1 | |||||||||
| CE39916 | |||||||||
| F14H12.4b | |||||||||
| CE39917 | |||||||||
| F14H12.4b.1 | |||||||||
| Other_name | cMST | Paper_evidence | WBPaper00046589 | ||||||
| CELE_F14H12.4 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | cst-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 30 Jun 2006 11:51:09 | WBPerson2970 | Name_change | CGC_name | cst-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cst | ||||||||
| Allele (42) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (36) | |||||||||
| Paralog (27) | |||||||||
| Structured_description | Concise_description | cst-1 encodes one of two C. elegans protein kinases orthologous to the MST (mammalian Ste20-like) kinases and Drosophila Hippo; CST-1 appears to play a role in the responses to oxidative stress and determination of adult lifespan; in regulating stress response and lifespan, CST-1 functions upstream of the DAF-16/FOXO transcription factor; CST-1 physically interacts with RSF-1, the C. elegans homolog of the Ras-association domain family protein 1. | Paper_evidence | WBPaper00027662 | |||||
| WBPaper00041685 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Mar 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein serine/threonine kinase activity. Involved in determination of adult lifespan and muscle cell development. Predicted to be located in cytoplasm. Expressed in hypodermis; sensory neurons; terminal bulb; and vulva. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is an ortholog of human STK3 (serine/threonine kinase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11408) | ||||
| Molecular_info | Corresponding_CDS | F14H12.4a | |||||||
| F14H12.4b | |||||||||
| Corresponding_CDS_history | F14H12.4a:wp155 | ||||||||
| F14H12.4b:wp155 | |||||||||
| Corresponding_transcript | F14H12.4a.1 | ||||||||
| F14H12.4b.1 | |||||||||
| Other_sequence (44) | |||||||||
| Associated_feature | WBsf1004907 | ||||||||
| WBsf1004908 | |||||||||
| WBsf1022768 | |||||||||
| WBsf1022769 | |||||||||
| WBsf235569 | |||||||||
| WBsf235570 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr3929 | ||||||||
| Expr13233 | |||||||||
| Expr1148618 | |||||||||
| Expr2010562 | |||||||||
| Expr2028802 | |||||||||
| Drives_construct | WBCnstr00011754 | ||||||||
| WBCnstr00015996 | |||||||||
| WBCnstr00027271 | |||||||||
| WBCnstr00038935 | |||||||||
| Construct_product | WBCnstr00015996 | ||||||||
| WBCnstr00027271 | |||||||||
| WBCnstr00038935 | |||||||||
| Microarray_results (14) | |||||||||
| Expression_cluster (87) | |||||||||
| Interaction (13) | |||||||||
| Map_info | Map | X | Position | -7.77494 | Error | 0.003139 | |||
| Positive | Positive_clone | F14H12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
