WormBase Tree Display for Gene: WBGene00017644

WBGene00017644 SMap: S_parent: Sequence: F20D12
  Identity: Version: 3
    Name: CGC_name: exc-9 Person_evidence: WBPerson1052
      Sequence_name: F20D12.5
      Molecular_name: F20D12.5
        F20D12.5.1
        CE29767
        F20D12.5.2
      Other_name: tag-291 Curator_confirmed: WBPerson2970
        CELE_F20D12.5 Accession_evidence: NDB BX284604
      Public_name: exc-9
    DB_info: Database: AceView gene 4I704
        WormQTL gene WBGene00017644
        WormFlux gene WBGene00017644
        NDB locus_tag CELE_F20D12.5
        Panther gene CAEEL|WormBase=WBGene00017644|UniProtKB=Q19641
          family PTHR24215
        NCBI gene 177586
        RefSeq protein NM_068925.6
        TrEMBL UniProtAcc Q19641
        UniProt_GCRP UniProtAcc Q19641
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:59 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 22 Apr 2005 11:55:18 WBPerson2970 Name_change: CGC_name: tag-291
        3 22 Jul 2005 13:21:27 WBPerson2970 Event: Acquires_merge: WBGene00001370
              Name_change: CGC_name: exc-9
                Other_name: tag-291
      Acquires_merge: WBGene00001370
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: exc
    Allele (16)
    Possibly_affected_by: WBVar02154074
    Legacy_information: [Buechner M] Wide, meandering excretory canals, with some septate cysts. Canal enlargement visible from L1 through adult. Defect visible only by Nomarksi microscopy.
    Complementation_data: [Buechner M] complements exc-5(rh232), exc-5(n2672)
    Strain: WBStrain00027275
      WBStrain00036217
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (30)
    Paralog: WBGene00003375 Caenorhabditis elegans From_analysis: Panther
      WBGene00015216 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000438 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00002987 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00002988 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00003000 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00003167 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006654 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006824 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022518 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: exc-9 encodes one of two C. elegans small LIM domain-containing proteins related to the mammalian CRIP (Cysteine-Rich Intestinal Protein) family of proteins; in C. elegans, exc-9 activity is required cell autonomously for proper organization of the apical cytoskeleton of the excretory canal cell, which is essential for maintaining the diameter of the excretory canal tubules; in addition, exc-9 is required for proper morphogenesis of the hermaphrodite and male tails; genetic analyses indicated that exc-9 likely functions upstream of exc-5, which encodes a guanine-nucleotide exchange factor, and downstream of exc-2 and sma-1, in regulating canal cell morphology; an EXC-9::GFP fusion protein is expressed in a number of cell types including the excretory canal cell, the tail spike, the uterine seam cell and anchor cell, the intestine, ALM and PLN neurons, and the nerve ring; in males, EXC-9::GFP expression is seen in a few tail neurons and weakly throughout the tail during larval development; EXC-9::GFP localizes to the cytoplasm; in yeast two-hybrid assays, EXC-9 interacts with CSN-5, a subunit of the COP9 signalosome likely involved in ubiquitin-mediated protein degradation. Paper_evidence: WBPaper00003721
            WBPaper00027309
            WBPaper00031650
          Curator_confirmed: WBPerson1843
          Date_last_updated: 18 Nov 2008 00:00:00
      Automated_description: Predicted to enable zinc ion binding activity. Involved in anatomical structure morphogenesis; epithelial cell development; and regulation of tube size. Located in cytoplasm. Expressed in several structures, including ALM; distal tip cell; excretory canal; lumbar ganglion; and nerve ring. Is an ortholog of human CRIP1 (cysteine rich protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F20D12.5
    Corresponding_transcript: F20D12.5.1
      F20D12.5.2
    Other_sequence (69)
    Associated_feature: WBsf651968
      WBsf230357
    Transcription_factor: WBTranscriptionFactor000457
  Experimental_info: RNAi_result: WBRNAi00077722 Inferred_automatically: RNAi_primary
      WBRNAi00033560 Inferred_automatically: RNAi_primary
      WBRNAi00045105 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8076
      Expr8077
      Expr12552
      Expr15546
      Expr1016400
      Expr1149055
      Expr2011394
      Expr2029630
    Drives_construct (12)
    Construct_product: WBCnstr00013093
    Microarray_results (17)
    Expression_cluster (180)
    Interaction (40)
  Map_info: Map: IV Position: 3.50307 Error: 0.000634
    Positive: Positive_clone: F20D12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 7084
      Multi_point: 5222
        3780
        3809
        3781
        3808
      Pos_neg_data: 10259
        10260
        10261
        10262
  Reference (25)
  Remark: n2669 was previously listed as an allele of exc-5. Later repeated complementation tests showed n2669 to be an allele of a novel locus positioned close to exc-5.
  Method: Gene