WormBase Tree Display for Gene: WBGene00017895
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| WBGene00017895 | SMap | S_parent | Sequence | F28B12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | vrk-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F28B12.3 | ||||||||
| Molecular_name | F28B12.3 | ||||||||
| F28B12.3.1 | |||||||||
| CE02704 | |||||||||
| F28B12.3.2 | |||||||||
| Other_name | tag-223 | Person_evidence | WBPerson201 | ||||||
| CELE_F28B12.3 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | vrk-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:59 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 22 Dec 2004 16:59:41 | WBPerson2970 | Name_change | CGC_name | tag-223 | ||||
| 3 | 19 Aug 2005 17:46:41 | WBPerson2970 | Name_change | CGC_name | vrk-1 | ||||
| Other_name | tag-223 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vrk | ||||||||
| Allele (44) | |||||||||
| Strain | WBStrain00035995 | ||||||||
| WBStrain00003833 | |||||||||
| WBStrain00003839 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Contained_in_operon | CEOP2747 | ||||||||
| Ortholog (47) | |||||||||
| Paralog (93) | |||||||||
| Structured_description | Concise_description | vrk-1 encodes the ortholog of the vaccinia-related protein kinases in metazoans; vrk-1 is required for normal mitosis, proper nuclear envelope formation and regulates the association of the LEM domain protein BAF-1/Barrier-to-autointegration factor (and possibly other LEM domain proteins) with chromatin via BAF-1 phosphorylation; vrk-1 is required for germ cell proliferation and acts in part through regulation of CEP-1/p53; vrk-1 is also required for development of the egg-laying system including several processes like formation of the vulva, the specification and proliferation of uterine cells and sex myoblasts, and anchor cell invasion of the basement membrane between the vulva and somatic gonad; VRK-1 is expressed in neurons, hypodermal cells and vulval cells, and localizes to the nuclear envelope and chromatin in a cell-cylce dependent manner. | Paper_evidence | WBPaper00028895 | |||||
| WBPaper00035100 | |||||||||
| WBPaper00036429 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 Apr 2011 00:00:00 | ||||||||
| Automated_description | Enables protein kinase activity. Involved in several processes, including cell fate specification; gonad development; and regulation of fibroblast growth factor receptor signaling pathway. Located in nuclear envelope. Part of chromatin. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; hermaphrodite gonad; and ventral nerve cord. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1A. Is an ortholog of human VRK1 (VRK serine/threonine kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060265 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12718) | ||||
| EFO:MONDO:0015363 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12718) | ||||||
| Molecular_info | Corresponding_CDS | F28B12.3 | |||||||
| Corresponding_transcript | F28B12.3.1 | ||||||||
| F28B12.3.2 | |||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf644245 | ||||||||
| WBsf657645 | |||||||||
| WBsf987996 | |||||||||
| WBsf221370 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00004028 | ||||||||
| WBCnstr00005735 | |||||||||
| WBCnstr00005736 | |||||||||
| WBCnstr00013241 | |||||||||
| WBCnstr00022497 | |||||||||
| WBCnstr00022498 | |||||||||
| WBCnstr00022499 | |||||||||
| WBCnstr00022500 | |||||||||
| WBCnstr00042078 | |||||||||
| Construct_product | WBCnstr00005735 | ||||||||
| WBCnstr00005736 | |||||||||
| WBCnstr00013706 | |||||||||
| WBCnstr00022497 | |||||||||
| WBCnstr00022498 | |||||||||
| WBCnstr00022499 | |||||||||
| WBCnstr00022500 | |||||||||
| WBCnstr00022501 | |||||||||
| WBCnstr00042078 | |||||||||
| Regulate_expr_cluster | WBPaper00060273:vrk-1(RNAi)_downregulated | ||||||||
| WBPaper00060273:vrk-1(RNAi)_upregulated | |||||||||
| Antibody | WBAntibody00001197 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (140) | |||||||||
| Interaction (189) | |||||||||
| Map_info | Map | II | Position | -0.846215 | Error | 0.001787 | |||
| Positive | Positive_clone | F28B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4878 | |||||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
