WormBase Tree Display for Gene: WBGene00017973

WBGene00017973 SMap: S_parent: Sequence: F32A6
  Identity: Version: 2
    Name: CGC_name: ift-81 Person_evidence: WBPerson426
      Sequence_name: F32A6.2
      Molecular_name: F32A6.2
        F32A6.2.1
        CE41565
      Other_name: CELE_F32A6.2 Accession_evidence: NDB BX284606
      Public_name: ift-81
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:59 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 19 Sep 2007 10:26:44 WBPerson1849 Event: Acquires_merge: WBGene00017972
              Name_change: CGC_name: ift-81
      Acquires_merge: WBGene00017972
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ift
    Allele (143)
    Strain: WBStrain00002530
      WBStrain00036344
      WBStrain00036504
      WBStrain00007576
      WBStrain00051699
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (32)
    Structured_description: Concise_description: ift-81 encodes an ortholog of the intraflagellar transport component IFT-81 in Chlamydomonas; ift-81 along with ift-74 is involved in growth, chemotaxis, intraflagellar transport and the morphogenesis of cilia; ift-81 binds ift-74 in protein binding assays and co-localizes with ift-74 to the transition zone of cilia in neurons, indicating that ift-81 may form a complex with ift-74. Paper_evidence: WBPaper00030726
          Curator_confirmed: WBPerson324
          Date_last_updated: 27 Oct 2008 00:00:00
      Automated_description: Enables microtubule binding activity. Involved in chemotaxis; detection of stimulus involved in sensory perception; and intraciliary transport. Located in non-motile cilium. Expressed in amphid neurons; chemosensory neurons; and phasmid neurons. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Is an ortholog of human IFT81 (intraflagellar transport 81). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080295 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14313)
  Molecular_info: Corresponding_CDS: F32A6.2
    Corresponding_CDS_history: F32A6.2:wp99
      F32A6.2:wp182
      F32A6.2:wp191
      F32A6.2:wp196
      F32A6.2:wp213
    Corresponding_transcript: F32A6.2.1
    Other_sequence: EL890803.1
      BM01040
    Associated_feature: WBsf648096
      WBsf662772
      WBsf662773
      WBsf1005231
      WBsf1005232
  Experimental_info: RNAi_result: WBRNAi00031647 Inferred_automatically: RNAi_primary
      WBRNAi00046081 Inferred_automatically: RNAi_primary
      WBRNAi00046082 Inferred_automatically: RNAi_primary
      WBRNAi00014197 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4638
      Expr5927
      Expr8322
      Expr1026677
      Expr1037733
      Expr1149971
      Expr2012699
      Expr2030935
    Drives_construct: WBCnstr00003106
      WBCnstr00012142
      WBCnstr00013259
    Construct_product: WBCnstr00013259
    Microarray_results (37)
    Expression_cluster: WBPaper00027022:cnb-1(jh103)_downregulated
      WBPaper00032528:L3_depleted
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_embryo_enriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_CoreEnriched
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00045050:csr-1(hypomorph)_upregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055103:thoc-5(wy822)_upregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056167:ifo-1(kc2)_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_L1
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059763:neuron_acr-2(n2420gf)_regulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADE
      WBPaper00061340:ADF
      WBPaper00061340:ADF_AWB
      WBPaper00061340:ADL
      WBPaper00061340:AFD
      WBPaper00061340:ASE
      WBPaper00061340:ASE_parent
      WBPaper00061340:ASG
      WBPaper00061340:ASG_AWA
      WBPaper00061340:ASH
      WBPaper00061340:ASI
      WBPaper00061340:ASI_parent
      WBPaper00061340:ASJ
      WBPaper00061340:ASK
      WBPaper00061340:ASK_parent
      WBPaper00061340:AUA
      WBPaper00061340:AWA
      WBPaper00061340:AWB
      WBPaper00061340:AWC
      WBPaper00061340:BAG
      WBPaper00061340:CEP
      WBPaper00061340:IL1
      WBPaper00061340:IL1_parent
      WBPaper00061340:IL2
      WBPaper00061340:Neuroblast_ADE_ADA
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061340:Neuroblast_HSN_PHB
      WBPaper00061340:Neuroblast_URX_CEPDx
      WBPaper00061340:OLL
      WBPaper00061340:OLL_parent
      WBPaper00061340:OLQ
      WBPaper00061340:OLQ_parent
      WBPaper00061340:URX
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061527:rab-28-jbts-14_9542
      WBPaper00061651:ADF_enriched
      WBPaper00061651:AQR_enriched
      WBPaper00061651:ASG_enriched
      WBPaper00061651:ASI_enriched
      WBPaper00061651:ASJ_enriched
      WBPaper00061651:ASK_enriched
      WBPaper00061651:CEP_enriched
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061651:IL2_LR_enriched
      WBPaper00061651:OLL_enriched
      WBPaper00061651:PDE_enriched
      WBPaper00061651:PHA_enriched
      WBPaper00061651:PHB_enriched
      WBPaper00061651:PQR_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061853:osm-3(dh441)_downregulated
      WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062056:efl-1(se1)_upregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064933:L1_secret_protein
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065841:25_0
      WBPaper00065841:25_1
      WBPaper00065841:35_1
      WBPaper00065841:35_4
      WBPaper00065841:36_0
      WBPaper00065841:36_2
      WBPaper00065841:36_3
      WBPaper00065841:39_0
      WBPaper00065841:39_1
      WBPaper00065841:39_2
      WBPaper00065841:39_3
      WBPaper00065841:44_0
      WBPaper00065841:44_1
      WBPaper00065841:47_0
      WBPaper00065841:50_0
      WBPaper00065841:63_0
      WBPaper00065841:71_0
      WBPaper00065841:72_0
      WBPaper00065841:77_0
      WBPaper00065841:84_0
      WBPaper00065841:99_0
      WBPaper00065841:100_0
      WBPaper00065841:122_0
      WBPaper00065841:131_0
      WBPaper00065841:138_0
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_19
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027111:rde-3(r459)_upregulated
      WBPaper00027111:rrf-2(ok210)_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00034739:N2moreDR1350
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
    Interaction (17)
  Map_info: Map: X Position: -5.72774 Error: 0.007898
    Positive: Positive_clone: F32A6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene