ift-81 encodes an ortholog of the intraflagellar transport component IFT-81 in Chlamydomonas; ift-81 along with ift-74 is involved in growth, chemotaxis, intraflagellar transport and the morphogenesis of cilia; ift-81 binds ift-74 in protein binding assays and co-localizes with ift-74 to the transition zone of cilia in neurons, indicating that ift-81 may form a complex with ift-74.
Enables microtubule binding activity. Involved in chemotaxis; detection of stimulus involved in sensory perception; and intraciliary transport. Located in non-motile cilium. Expressed in amphid neurons; chemosensory neurons; and phasmid neurons. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Is an ortholog of human IFT81 (intraflagellar transport 81).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.