WormBase Tree Display for Gene: WBGene00017990
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| WBGene00017990 | SMap | S_parent | Sequence | F32E10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cec-4 | Person_evidence | WBPerson437 | |||||
| Sequence_name | F32E10.2 | ||||||||
| Molecular_name | F32E10.2 | ||||||||
| F32E10.2.1 | |||||||||
| CE04475 | |||||||||
| F32E10.2.2 | |||||||||
| Other_name | CELE_F32E10.2 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | cec-4 | ||||||||
| DB_info | Database | AceView | gene | 4I341 | |||||
| WormQTL | gene | WBGene00017990 | |||||||
| WormFlux | gene | WBGene00017990 | |||||||
| NDB | locus_tag | CELE_F32E10.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00017990|UniProtKB=Q19972 | |||||||
| family | PTHR10503 | ||||||||
| NCBI | gene | 177536 | |||||||
| RefSeq | protein | NM_068830.10 | |||||||
| SwissProt | UniProtAcc | Q19972 | |||||||
| UniProt_GCRP | UniProtAcc | Q19972 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:59 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 30 Sep 2011 16:40:15 | WBPerson2970 | Name_change | CGC_name | cec-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cec | ||||||||
| Allele (26) | |||||||||
| Strain | WBStrain00032979 | ||||||||
| WBStrain00050681 | |||||||||
| WBStrain00050687 | |||||||||
| WBStrain00050688 | |||||||||
| WBStrain00051706 | |||||||||
| WBStrain00054542 | |||||||||
| WBStrain00053676 | |||||||||
| WBStrain00054543 | |||||||||
| WBStrain00053675 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (27) | |||||||||
| Paralog | WBGene00001996 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00010363 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00021913 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00017993 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WBGene00195045 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00194861 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | cec-4 is an ortholog of human CBX1 (chromobox 1), CBX5 (chromobox 5) and CBX3 (chromobox 3); CEC-4 is required for the perinuclear anchoring of chromatin methylated on histone H3 Lysine 9 (H3K9) in embryos; the CEC-4 chromodomain is 42% identical to human CBX1 (chromobox 1) chromodomain and CBX5 (chromobox 5) chromodomain; CEC-4 has a large C-terminal domain that does not have homology to other known proteins; it has no chromoshadow domain, and no hinge domain and is therefore not a homolog of HP1; CEC-4-tagged version is expressed in all developmental stages of the worm life cycle, and it is localized to the inner nuclear membrane, positioned between nuclear pores; CEC-4 binds all methylated forms of H3K9 with similar affinities in in vitro assays; cec-4(ok3124) allele supports normal development and does not affect fertility. | Paper_evidence | WBPaper00048885 | |||||
| Person_evidence | WBPerson3045 | ||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 08 Mar 2016 00:00:00 | ||||||||
| Automated_description | Enables methylated histone binding activity. Involved in chromosome attachment to the nuclear envelope; regulation of cell differentiation; and regulation of gene expression. Located in nuclear inner membrane. Expressed in germ cell and somatic cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F32E10.2 | |||||||
| Corresponding_transcript | F32E10.2.1 | ||||||||
| F32E10.2.2 | |||||||||
| Other_sequence | CRC00089_1 | ||||||||
| CR01126 | |||||||||
| CR00528 | |||||||||
| CBC13290_1 | |||||||||
| Associated_feature | WBsf646096 | ||||||||
| WBsf646097 | |||||||||
| WBsf655008 | |||||||||
| WBsf660308 | |||||||||
| WBsf228550 | |||||||||
| WBsf228551 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr12611 | ||||||||
| Expr1018597 | |||||||||
| Expr1037745 | |||||||||
| Expr1150031 | |||||||||
| Expr2009835 | |||||||||
| Expr2028075 | |||||||||
| Drives_construct | WBCnstr00022443 | ||||||||
| WBCnstr00022445 | |||||||||
| WBCnstr00026860 | |||||||||
| Construct_product | WBCnstr00022443 | ||||||||
| WBCnstr00022445 | |||||||||
| WBCnstr00026860 | |||||||||
| Regulate_expr_cluster | WBPaper00050193:cec-4(ok3124)_downregulated_L1 | ||||||||
| WBPaper00050193:cec-4(ok3124)_upregulated_L1 | |||||||||
| WBPaper00059378:cec-4(ok3124);lmn-1(WT)_vs_lmn-1(WT)_downregulated | |||||||||
| WBPaper00059378:cec-4(ok3124);lmn-1(WT)_vs_lmn-1(WT)_upregulated | |||||||||
| WBPaper00059378:cec-4(ok3124);lmn-1(Y59C)_vs_lmn-1(Y59C)_downregulated | |||||||||
| WBPaper00059378:cec-4(ok3124);lmn-1(Y59C)_vs_lmn-1(Y59C)_upregulated | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (111) | |||||||||
| Map_info | Map | IV | Position | 3.35786 | Error | 0.000254 | |||
| Positive | Positive_clone | F32E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
