WormBase Tree Display for Gene: WBGene00018008

WBGene00018008 SMap: S_parent: Sequence: F33D11
  Identity: Version: 2
    Name: CGC_name: vpr-1 Person_evidence: WBPerson425
      Sequence_name: F33D11.11
      Molecular_name: F33D11.11
        F33D11.11.1
        CE09902
      Other_name: CELE_F33D11.11 Accession_evidence: NDB BX284601
      Public_name: vpr-1
    DB_info: Database: AceView gene 1G446
        WormQTL gene WBGene00018008
        WormFlux gene WBGene00018008
        NDB locus_tag CELE_F33D11.11
        Panther gene CAEEL|WormBase=WBGene00018008|UniProtKB=O44782
          family PTHR10809
        NCBI gene 172259
        RefSeq protein NM_001383165.2
        TrEMBL UniProtAcc O44782
        UniProt_GCRP UniProtAcc O44782
        OMIM gene 605704
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:59 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 15 Nov 2007 11:36:32 WBPerson2970 Name_change: CGC_name: vpr-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vpr
    Allele (22)
    Strain: WBStrain00036627
    RNASeq_FPKM (74)
    GO_annotation (13)
    Contained_in_operon: CEOP1284
    Ortholog (42)
    Paralog (41)
    Structured_description: Concise_description: vpr-1 encodes the C. elegans VAP (VAMP-associated protein) ortholog, a transmembrane protein containing an N-terminal extracellular major sperm protein (MSP) domain; loss of vpr-1 function during development indicates that vpr-1 is required, both in vab-1-dependent and vab-1-independent pathways, for proper distal tip cell migration during somatic gonad development, ventral hypodermal cell migrations during embryonic enclosure, and anteriorly directed amphid neuron migration; like C. elegans MSPs, injection of the VPR-1 MSP domain into fog-2 females induces oocyte maturation and gonadal sheath cell contraction; the VPR-1 MSP domain directly binds the VAB-1/Ephrin receptor extracellular domain in vitro and in vivo, binds the oocyte and gonadal sheath cell plasma membranes. Paper_evidence: WBPaper00004591
            WBPaper00031951
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2008 00:00:00
      Automated_description: Enables ephrin receptor binding activity and protein domain specific binding activity. Predicted to be involved in endoplasmic reticulum membrane organization and endoplasmic reticulum-plasma membrane tethering. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Expressed in several structures, including body wall musculature; gonad; intestine; muscle cell; and nervous system. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 8 and autosomal dominant adult-onset proximal spinal muscular atrophy. Is an ortholog of human VAPA (VAMP associated protein A) and VAPB (VAMP associated protein B and C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:332 Homo sapiens Paper_evidence: WBPaper00031951
          Curator_confirmed: WBPerson38202
          Date_last_updated: 22 May 2018 00:00:00
    Potential_model: DOID:12377 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12649)
      DOID:332 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12649)
      DOID:0111194 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12649)
      DOID:0050752 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12649)
  Models_disease_asserted: WBDOannot00000522
  Molecular_info: Corresponding_CDS: F33D11.11
    Corresponding_transcript: F33D11.11.1
    Other_sequence (37)
    Associated_feature: WBsf649197
      WBsf976710
      WBsf976711
      WBsf976712
      WBsf976713
      WBsf976714
      WBsf983788
      WBsf1009874
      WBsf219501
  Experimental_info: RNAi_result: WBRNAi00014243 Inferred_automatically: RNAi_primary
      WBRNAi00080641 Inferred_automatically: RNAi_primary
      WBRNAi00033494 Inferred_automatically: RNAi_primary
      WBRNAi00116197 Inferred_automatically: RNAi_primary
      WBRNAi00116215 Inferred_automatically: RNAi_primary
      WBRNAi00046191 Inferred_automatically: RNAi_primary
      WBRNAi00117072 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9928
      Expr9929
      Expr15955
      Expr15956
      Expr1028732
      Expr1037756
      Expr1150079
      Expr2018008
      Expr2036145
    Drives_construct: WBCnstr00014939
      WBCnstr00014940
      WBCnstr00026843
    Construct_product: WBCnstr00014940
      WBCnstr00026843
      WBCnstr00042622
    Microarray_results (21)
    Expression_cluster (127)
    Interaction (58)
    Anatomy_function: WBbtf0672
      WBbtf0673
      WBbtf0674
      WBbtf0675
      WBbtf0676
      WBbtf0677
      WBbtf0678
  Map_info: Map: I Position: 0.471902 Error: 0.000212
    Positive: Positive_clone: F33D11 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (24)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene