WormBase Tree Display for Gene: WBGene00018319
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| WBGene00018319 | SMap | S_parent | Sequence | F41H10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | hda-6 | Person_evidence | WBPerson260 | |||||
| WBPerson2136 | |||||||||
| Sequence_name | F41H10.6 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | hdac-6 | Paper_evidence | WBPaper00005214 | ||||||
| Person_evidence | WBPerson2136 | ||||||||
| Y4C6B.a | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_F41H10.6 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | hda-6 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 02 Nov 2009 10:01:13 | WBPerson9133 | Name_change | CGC_name | hdac-6 | ||||
| 3 | 12 Apr 2012 16:15:43 | WBPerson2970 | Name_change | CGC_name | hda-6 | ||||
| Other_name | hdac-6 | ||||||||
| Status | Live | ||||||||
| Gene_info (10) | |||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00041253 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Nov 2013 00:00:00 | ||||||||
| Potential_model | DOID:8991 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14064) | |||||
| DOID:4947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14064) | ||||||
| DOID:0112106 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14064) | ||||||
| DOID:0050770 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14064) | ||||||
| Disease_relevance | In elegans, alpha-synuclein (alpha-syn) toxicity, implicated in Parkinson''s disease and other synucleinopathies, is modeled by expressing it from the dopamine transporter (dat-1) gene promotor in transgenic GFP worms, resulting in an age-dependent progressive loss of dopaminergic neurons; using this system, it was seen that the knock-down of specific candidate genes in elegans, that interact with catp-6/ATP13A2, resulted in significant enhancement of alpha-syn-induced dopaminergic neurodegeneration; these catp-6/ATP13A2 interactors include the elegans ortholog of histone deacetylase 6 (hda-6), coagulation factor II (thrombin) receptor (dop-2), AP2 associated kinase 1 (AAK1; sel-5) along with neuropeptide Y receptor Y1 (npr-4), and YIP1 interacting factor homolog A (yif-1). | Homo sapiens | Paper_evidence | WBPaper00041253 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Nov 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000249 | ||||||||
| Molecular_info | Corresponding_CDS | F41H10.6a | |||||||
| F41H10.6b | |||||||||
| F41H10.6c | |||||||||
| F41H10.6d | |||||||||
| Corresponding_transcript | F41H10.6a.1 | ||||||||
| F41H10.6b.1 | |||||||||
| F41H10.6c.1 | |||||||||
| F41H10.6d.1 | |||||||||
| Other_sequence (43) | |||||||||
| Associated_feature | WBsf651797 | ||||||||
| WBsf996488 | |||||||||
| WBsf230078 | |||||||||
| WBsf230079 | |||||||||
| WBsf230080 | |||||||||
| Experimental_info (8) | |||||||||
| Map_info | Map | IV | Position | 1.59535 | Error | 0.000683 | |||
| Positive | Positive_clone | F41H10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
