WormBase Tree Display for Gene: WBGene00018468
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| WBGene00018468 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 5 | |||||||
| Name | CGC_name | cla-1 | Person_evidence | WBPerson15241 | |||||
| WBPerson1781 | |||||||||
| WBPerson3194 | |||||||||
| WBPerson39938 | |||||||||
| Sequence_name | F45E4.3 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | tag-199 | Person_evidence | WBPerson201 | ||||||
| F32E10.7 | |||||||||
| F45E4.4 | |||||||||
| tag-80 | Person_evidence | WBPerson201 | |||||||
| CELE_F45E4.3 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | cla-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 06 Jan 2014 14:11:37 | WBPerson4025 | Event | Acquires_merge | WBGene00017994 | ||||
| 3 | 06 Jan 2014 14:11:37 | WBPerson1983 | Event | Acquires_merge | WBGene00006453 | ||||
| 4 | 06 Jan 2014 14:11:37 | WBPerson1983 | Event | Acquires_merge | WBGene00007061 | ||||
| Name_change | CGC_name | tag-80 | |||||||
| Other_name | tag-199 | ||||||||
| 5 | 28 Apr 2017 12:23:43 | WBPerson2970 | Name_change | CGC_name | cla-1 | ||||
| Other_name | tag-80 | ||||||||
| Acquires_merge | WBGene00006453 | ||||||||
| WBGene00007061 | |||||||||
| WBGene00017994 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cla | ||||||||
| Allele (412) | |||||||||
| Possibly_affected_by | WBVar02158619 | ||||||||
| Strain | WBStrain00032001 | ||||||||
| WBStrain00031491 | |||||||||
| WBStrain00032468 | |||||||||
| WBStrain00035728 | |||||||||
| WBStrain00035905 | |||||||||
| WBStrain00036025 | |||||||||
| WBStrain00035934 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (43) | |||||||||
| Structured_description | Concise_description | F45E4.3 encodes a protein containing C-terminal PDZ and C2 Ca2+-binding domains that is related to the mammalian active zone protein Piccolo/Aczonin; loss of F45E4.3 activity has been reported to result in uncoordinated locomotion, suggesting that F45E4.3 plays a role in the organization and/or function of the neuromuscular system. | Paper_evidence | WBPaper00024200 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 11 Apr 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in maintenance of presynaptic active zone structure; spontaneous synaptic transmission; and synaptic vesicle cycle. Located in presynaptic active zone. Expressed in nervous system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Is an ortholog of human BSN (bassoon presynaptic cytomatrix protein) and PCLO (piccolo presynaptic cytomatrix protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060272 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13406) | ||||
| Molecular_info | Corresponding_CDS | F45E4.3a | |||||||
| F45E4.3b | |||||||||
| F45E4.3c | |||||||||
| F45E4.3d | |||||||||
| F45E4.3e | |||||||||
| F45E4.3f | |||||||||
| Corresponding_CDS_history | F45E4.3a:wp241 | ||||||||
| F45E4.3a:wp249 | |||||||||
| F45E4.3b:wp241 | |||||||||
| F45E4.3b:wp249 | |||||||||
| Corresponding_transcript | F45E4.3a.1 | ||||||||
| F45E4.3b.1 | |||||||||
| F45E4.3c.1 | |||||||||
| F45E4.3d.1 | |||||||||
| F45E4.3e.1 | |||||||||
| F45E4.3f.1 | |||||||||
| Other_sequence (17) | |||||||||
| Associated_feature (22) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern (21) | |||||||||
| Drives_construct | WBCnstr00026494 | ||||||||
| Construct_product | WBCnstr00026494 | ||||||||
| Microarray_results (83) | |||||||||
| Expression_cluster (307) | |||||||||
| Interaction (32) | |||||||||
| Map_info | Map | IV | Position | 3.365 | |||||
| Positive | Positive_clone | F45E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4439 | |||||||
| 5593 | |||||||||
| 5633 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
