WormBase Tree Display for Gene: WBGene00018591
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| WBGene00018591 | SMap | S_parent | Sequence | F48B9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | npax-2 | Paper_evidence | WBPaper00003599 | |||||
| Person_evidence | WBPerson260 | ||||||||
| Sequence_name | F48B9.5 | ||||||||
| Molecular_name | F48B9.5 | ||||||||
| F48B9.5.1 | |||||||||
| CE35546 | |||||||||
| Other_name | CELE_F48B9.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | npax-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 28 May 2010 15:24:57 | WBPerson2970 | Name_change | CGC_name | npax-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | npax | ||||||||
| Allele (34) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00068390 | ||||||||
| 00068391 | |||||||||
| 00068392 | |||||||||
| 00068393 | |||||||||
| 00068394 | |||||||||
| 00068395 | |||||||||
| 00068396 | |||||||||
| 00123686 | |||||||||
| 00123687 | |||||||||
| Ortholog (26) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | npax-2 is a divergent Paired domain-only protein; the second part of the Paired domain (RED subdomain) is quite divergent; the Paired domain is a DNA-binding domain; npax genes mostly diverged from complete Paired domain-only and/or Paired homeobox genes; no obvious orthologs are present in arthropods or vertebrates; unlike npax-1, npax-3, and npax-4, npax-2 has both a PAI and RED subdomain, i.e. a full Paired domain; the RED domain became apparent, when previously unrecognised C-terminal exons were included in the open reading frame (ORF). | Paper_evidence | WBPaper00029055 | |||||
| WBPaper00003599 | |||||||||
| WBPaper00046864 | |||||||||
| WBPaper00051112 | |||||||||
| Person_evidence | WBPerson83 | ||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Apr 2017 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Expressed in head neurons; hypodermis; and vulF. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple) and diabetic ketoacidosis. Is an ortholog of human PAX4 (paired box 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8618) | ||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8618) | ||||||
| DOID:0111107 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8618) | ||||||
| DOID:1837 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8618) | ||||||
| Molecular_info | Corresponding_CDS | F48B9.5 | |||||||
| Corresponding_CDS_history | F48B9.5:wp108 | ||||||||
| Corresponding_transcript | F48B9.5.1 | ||||||||
| Other_sequence | JI175891.1 | ||||||||
| JI461007.1 | |||||||||
| CK726080.1 | |||||||||
| WBC03339_1 | |||||||||
| HG00866 | |||||||||
| Dviv_isotig19041 | |||||||||
| OOC03437_1 | |||||||||
| TCC00528_1 | |||||||||
| TX02063 | |||||||||
| HGC02025_1 | |||||||||
| Associated_feature | WBsf718515 | ||||||||
| WBsf978749 | |||||||||
| WBsf1004238 | |||||||||
| WBsf1004239 | |||||||||
| WBsf1004240 | |||||||||
| WBsf1004241 | |||||||||
| WBsf1022416 | |||||||||
| WBsf1022417 | |||||||||
| WBsf237058 | |||||||||
| Transcription_factor | WBTranscriptionFactor001016 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00047720 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00015234 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032471 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr7575 | ||||||||
| Expr1028637 | |||||||||
| Expr1151553 | |||||||||
| Expr2014362 | |||||||||
| Expr2032603 | |||||||||
| Drives_construct | WBCnstr00012720 | ||||||||
| WBCnstr00026398 | |||||||||
| Construct_product | WBCnstr00026398 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (26) | |||||||||
| Map_info | Map | X | Position | -16.9806 | Error | 0.017005 | |||
| Positive | Positive_clone | F48B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003599 | ||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
