WormBase Tree Display for Gene: WBGene00019004

WBGene00019004 SMap: S_parent: Sequence: F57B10
  Identity: Version: 2
    Name: CGC_name: xpg-1 Person_evidence: WBPerson1684
      Sequence_name: F57B10.6
      Molecular_name: F57B10.6
        F57B10.6.1
        CE45535
      Other_name: CELE_F57B10.6 Accession_evidence: NDB BX284601
      Public_name: xpg-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:01 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 03 Apr 2007 13:26:54 WBPerson2970 Name_change: CGC_name: xpg-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: xpg
    Allele (52)
    Strain: WBStrain00003814
      WBStrain00051059
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP1336
    Ortholog (31)
    Paralog: WBGene00000794 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009731 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020442 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: xpg-1 encodes an ortholog of human XPG (also known as ERCC5; mutations in this gene are associated with Cockayne Syndrome; OMIM:133530); xpg-1 is a core NER (Nuclear Excision Repair) factor (other members being xpf-1, xpa-1, and ercc-1); NER factors remove UV-induced DNA damage and have been demonstrated to be required for both the global genome repair (GGR) and transcription coupled repair (TCR) pathways; XPG-1 activity is essential for the survival of germ cells and somatic tissue following UV irradiation and is necessary for germ cells and embryos to survive even relatively low doses of UV irradiation; mutations in xpg-1, as well as in other NER factors, render animals hypersensitive to UV light. Paper_evidence: WBPaper00036260
          Person_evidence: WBPerson1684
          Curator_confirmed: WBPerson712
            WBPerson1823
            WBPerson567
          Date_last_updated: 25 Jul 2010 00:00:00
      Automated_description: Predicted to enable 5'-flap endonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; respiratory system cancer (multiple); and xeroderma pigmentosum group G. Is an ortholog of human ERCC5 (ERCC excision repair 5, endonuclease). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050117 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3437)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3437)
      DOID:0080913 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3437)
      DOID:0110849 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3437)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3437)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3437)
      DOID:1909 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3437)
      DOID:2596 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3437)
      DOID:3070 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3437)
  Molecular_info: Corresponding_CDS: F57B10.6
    Corresponding_CDS_history: F57B10.6:wp221
    Corresponding_transcript: F57B10.6.1
    Other_sequence (23)
    Associated_feature: WBsf656415
      WBsf656416
  Experimental_info: RNAi_result: WBRNAi00003841 Inferred_automatically: RNAi_primary
      WBRNAi00048822 Inferred_automatically: RNAi_primary
      WBRNAi00111804 Inferred_automatically: RNAi_primary
      WBRNAi00033010 Inferred_automatically: RNAi_primary
      WBRNAi00097146 Inferred_automatically: RNAi_primary
      WBRNAi00091420 Inferred_automatically: RNAi_primary
      WBRNAi00007704 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1025611
      Expr1038205
      Expr1152578
      Expr2018105
      Expr2036243
    Drives_construct: WBCnstr00026132
    Construct_product: WBCnstr00026132
    Microarray_results (20)
    Expression_cluster (119)
    Interaction (39)
  Map_info: Map: I Position: 1.21243 Error: 0.000479
    Positive: Positive_clone: F57B10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027223
    WBPaper00036260
    WBPaper00036708
    WBPaper00038491
    WBPaper00040448
    WBPaper00044163
    WBPaper00053104
    WBPaper00055090
    WBPaper00063908
    WBPaper00064312
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene