WormBase Tree Display for Gene: WBGene00019424
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| WBGene00019424 | SMap | S_parent | Sequence | K06A1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | aptf-1 | Person_evidence | WBPerson1997 | |||||
| Sequence_name | K06A1.1 | ||||||||
| Molecular_name | K06A1.1 | ||||||||
| K06A1.1.1 | |||||||||
| CE35990 | |||||||||
| Other_name | CELE_K06A1.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | aptf-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 18 Apr 2008 09:32:24 | WBPerson2970 | Name_change | CGC_name | aptf-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aptf | ||||||||
| Allele (16) | |||||||||
| Strain | WBStrain00036781 | ||||||||
| WBStrain00008308 | |||||||||
| WBStrain00008309 | |||||||||
| WBStrain00008310 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (52) | |||||||||
| Paralog | WBGene00009202 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00009203 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00013383 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | aptf-1 encodes one of four C. elegans AP-2-like transcription factors; APTF-1 activity is required in the RIS interneuron for sleep-like quiescence induced by neuropeptide signaling; aptf-1 is expressed in five head interneurons. | Paper_evidence | WBPaper00044407 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Mar 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and sleep. Predicted to be located in nucleus. Expressed in head neurons and pharyngeal neurons. Human ortholog(s) of this gene implicated in Char syndrome; branchiooculofacial syndrome; and dilated cardiomyopathy. Is an ortholog of human TFAP2C (transcription factor AP-2 gamma). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050691 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11742) | ||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11742) | ||||||
| DOID:0060563 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11743) | ||||||
| DOID:13832 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11743) | ||||||
| Molecular_info | Corresponding_CDS | K06A1.1 | |||||||
| Corresponding_CDS_history | K06A1.1:wp112 | ||||||||
| Corresponding_transcript | K06A1.1.1 | ||||||||
| Other_sequence (18) | |||||||||
| Associated_feature | WBsf978621 | ||||||||
| WBsf988169 | |||||||||
| WBsf221447 | |||||||||
| WBsf221448 | |||||||||
| WBsf221449 | |||||||||
| Transcription_factor | WBTranscriptionFactor000240 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00033998 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00050014 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022394 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr7607 | ||||||||
| Expr11364 | |||||||||
| Expr1018338 | |||||||||
| Expr1153707 | |||||||||
| Expr2009370 | |||||||||
| Expr2027606 | |||||||||
| Drives_construct | WBCnstr00012752 | ||||||||
| WBCnstr00018465 | |||||||||
| WBCnstr00018466 | |||||||||
| WBCnstr00018469 | |||||||||
| WBCnstr00018492 | |||||||||
| WBCnstr00022594 | |||||||||
| WBCnstr00022786 | |||||||||
| WBCnstr00022790 | |||||||||
| WBCnstr00025849 | |||||||||
| Construct_product | WBCnstr00018467 | ||||||||
| WBCnstr00018492 | |||||||||
| WBCnstr00018493 | |||||||||
| WBCnstr00021808 | |||||||||
| WBCnstr00025849 | |||||||||
| Regulate_expr_cluster | WBPaper00049336:aptf-1(gk794)_downregulated_3-fold-embryo | ||||||||
| WBPaper00049336:aptf-1(gk794)_downregulated_L4 | |||||||||
| WBPaper00049336:aptf-1(gk794)_upregulated_3-fold-embryo | |||||||||
| WBPaper00049336:aptf-1(gk794)_upregulated_L4 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (94) | |||||||||
| Interaction (50) | |||||||||
| Map_info | Map | II | Position | -0.231866 | Error | 0.002525 | |||
| Positive | Positive_clone | K06A1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
