WormBase Tree Display for Gene: WBGene00019600
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| WBGene00019600 | SMap | S_parent | Sequence | K09H11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | rga-3 | Person_evidence | WBPerson610 | |||||
| WBPerson351 | |||||||||
| Sequence_name | K09H11.3 | ||||||||
| Molecular_name | K09H11.3 | ||||||||
| K09H11.3.1 | |||||||||
| CE12052 | |||||||||
| Other_name | CELE_K09H11.3 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | rga-3 | ||||||||
| DB_info | Database | AceView | gene | 5G201 | |||||
| WormQTL | gene | WBGene00019600 | |||||||
| WormFlux | gene | WBGene00019600 | |||||||
| NDB | locus_tag | CELE_K09H11.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00019600|UniProtKB=O01585 | |||||||
| family | PTHR15670 | ||||||||
| NCBI | gene | 178961 | |||||||
| RefSeq | protein | NM_072102.4 | |||||||
| TREEFAM | TREEFAM_ID | TF317157 | |||||||
| TrEMBL | UniProtAcc | O01585 | |||||||
| UniProt_GCRP | UniProtAcc | O01585 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 08 Sep 2006 10:43:24 | WBPerson1847 | Name_change | CGC_name | rga-3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rga | ||||||||
| Allele (66) | |||||||||
| Strain | WBStrain00036596 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00022286 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | rga-3 encodes a GTPase-activating protein (GAP); RNAi experiments predicted to target rga-3 and the related rga-4 gene result in early embryonic defects, specifically defects in cortical contractility, non-muscle myosin NMY-2 distribution, and the relative size of PAR protein domains; in vitro, RGA-3 positively regulates RHO-1 GTPase activity, consistent with genetic studies showing that the rga-3/4(RNAi) phenotype requires RHO-1 activity; in early embryos, a YFP-RGA-3 fusion protein localizes to the cellular cortex and to centrosomes, with cortical localization segregating to the anterior during polarization. | Paper_evidence | WBPaper00031005 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Sep 2007 00:00:00 | ||||||||
| Automated_description | Enables GTPase activator activity. Involved in asymmetric protein localization involved in cell fate determination; cortical actin cytoskeleton organization; and regulation of actin filament-based process. Located in cell cortex and centrosome. Expressed in embryonic cell; germ line; and pharyngeal muscle cell. Is an ortholog of human ARHGAP11A (Rho GTPase activating protein 11A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K09H11.3 | |||||||
| Corresponding_transcript | K09H11.3.1 | ||||||||
| Associated_feature | WBsf231795 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00111063 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00008051 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00025930 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110632 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050459 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085766 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2076 | ||||||||
| Expr4990 | |||||||||
| Expr4991 | |||||||||
| Expr11004 | |||||||||
| Expr1018372 | |||||||||
| Expr1038463 | |||||||||
| Expr1154168 | |||||||||
| Expr2015315 | |||||||||
| Expr2033549 | |||||||||
| Drives_construct | WBCnstr00018692 | ||||||||
| WBCnstr00018693 | |||||||||
| WBCnstr00025740 | |||||||||
| Construct_product | WBCnstr00009311 | ||||||||
| WBCnstr00012395 | |||||||||
| WBCnstr00018692 | |||||||||
| WBCnstr00018693 | |||||||||
| WBCnstr00025740 | |||||||||
| Antibody | WBAntibody00001299 | ||||||||
| WBAntibody00002974 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (161) | |||||||||
| Interaction (21) | |||||||||
| Map_info | Map | V | Position | -1.14361 | Error | 0.023645 | |||
| Positive | Positive_clone | K09H11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
