WormBase Tree Display for Gene: WBGene00020131
expand all nodes | collapse all nodes | view schema
| WBGene00020131 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | gcy-28 | Person_evidence | WBPerson655 | |||||
| WBPerson260 | |||||||||
| WBPerson42 | |||||||||
| Sequence_name | T01A4.1 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | GCY-X1 | Paper_evidence | WBPaper00002821 | ||||||
| T01A4.1a | Paper_evidence | WBPaper00027040 | |||||||
| CELE_T01A4.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | gcy-28 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 28 Sep 2005 17:44:29 | WBPerson2970 | Name_change | CGC_name | gcy-38 | ||||
| 3 | 05 Jan 2006 11:22:21 | WBPerson2970 | Name_change | CGC_name | gcy-28 | ||||
| 4 | 09 Jan 2009 16:53:36 | WBPerson1849 | Event | Acquires_merge | WBGene00020132 | ||||
| Acquires_merge | WBGene00020132 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gcy | ||||||||
| Allele (415) | |||||||||
| Strain | WBStrain00029463 | ||||||||
| WBStrain00002485 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (47) | |||||||||
| Paralog (37) | |||||||||
| Structured_description | Concise_description | gcy-28 encodes a membrane-bound guanylyl cyclase with an extracellular ligand binding domain, a transmembrane domain, and a guanylyl cyclase domain; GCY-28 regulates odor preferences in AWC sensory neurons; gcy-28 regulates the sensory integration in the nervous system and that function of gcy-28 at adulthood is sufficient for normal sensory integration; GCY-28 in AIA interneurons is important for sensory integration; gcy-28 and cng-1 operate in the same genetic pathway to regulate sensory integration; GCY-28 and SCD-2 function in distinct pathways; gcy-28.c isoform is expressed in many neurons and gcy-28.d isoform is expressed specifically in a pair of interneurons, AIA. | Paper_evidence | WBPaper00038243 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 21 Jul 2011 00:00:00 | ||||||||
| Automated_description | Enables guanylate cyclase activity. Involved in chemotaxis; olfactory behavior; and sensory perception. Located in cell body and neuron projection. Expressed in body wall musculature; gonad; hypodermis; intestine; and neurons. Human ortholog(s) of this gene implicated in artery disease (multiple) and bone development disease (multiple). Is an ortholog of human NPR1 (natriuretic peptide receptor 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070316 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7944) | ||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7944) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7943) | ||||||
| DOID:0080050 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7944) | ||||||
| Molecular_info | Corresponding_CDS | T01A4.1a | |||||||
| T01A4.1b | |||||||||
| T01A4.1c | |||||||||
| T01A4.1d | |||||||||
| Corresponding_CDS_history | T01A4.1:wp21 | ||||||||
| Corresponding_transcript | T01A4.1a.1 | ||||||||
| T01A4.1b.1 | |||||||||
| T01A4.1c.1 | |||||||||
| T01A4.1d.1 | |||||||||
| Other_sequence (50) | |||||||||
| Associated_feature (30) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00116640 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00052063 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034987 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00117088 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00052064 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034986 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004093 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00008652 | ||||||||
| WBCnstr00008653 | |||||||||
| WBCnstr00008887 | |||||||||
| WBCnstr00008888 | |||||||||
| WBCnstr00013275 | |||||||||
| WBCnstr00013846 | |||||||||
| WBCnstr00018860 | |||||||||
| WBCnstr00042855 | |||||||||
| Antibody | WBAntibody00001816 | ||||||||
| Microarray_results (51) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (37) | |||||||||
| Map_info | Map | I | Position | -1.2688 | Error | 0.02488 | |||
| Positive | Positive_clone | T01A4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5726 | |||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | WBGene00020131 has been renamed from gcy-38 to gcy-28 | Person_evidence | WBPerson655 | ||||||
| WBPerson260 | |||||||||
| WBPerson42 | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
