WormBase Tree Display for Gene: WBGene00020490
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| WBGene00020490 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | tmc-1 | Person_evidence | WBPerson260 | |||||
| Sequence_name | T13G4.3 | ||||||||
| Molecular_name | T13G4.3 | ||||||||
| T13G4.3.1 | |||||||||
| CE37147 | |||||||||
| T13G4.3.2 | |||||||||
| Other_name | R193.f | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| T13G4.e | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_T13G4.3 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | tmc-1 | ||||||||
| DB_info | Database | AceView | gene | XB793 | |||||
| WormQTL | gene | WBGene00020490 | |||||||
| WormFlux | gene | WBGene00020490 | |||||||
| NDB | locus_tag | CELE_T13G4.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00020490|UniProtKB=D3KZG3 | |||||||
| family | PTHR23302 | ||||||||
| NCBI | gene | 188483 | |||||||
| RefSeq | protein | NM_075820.9 | |||||||
| SwissProt | UniProtAcc | D3KZG3 | |||||||
| UniProt_GCRP | UniProtAcc | D3KZG3 | |||||||
| OMIM | gene | 606706 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 20 Apr 2011 10:05:24 | WBPerson2970 | Name_change | CGC_name | tmc-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tmc | ||||||||
| Allele (278) | |||||||||
| Strain | WBStrain00032242 | ||||||||
| WBStrain00004936 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00015177 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | tmc-1 encodes a multipass transmembrane protein; TMC-1 functions specifically as a sodium-sensitive channel that is required for salt taste chemosensation in the ASH neurons and for high salt avoidance behavior; when expressed in other neurons, TMC-1 is sufficient to generate a salt response in vivo, and when expressed in mammalian cells, TMC-1 generates a predominantly cationic current activated by high extracellular sodium but not other cations or uncharged small molecules; tmc-1 is expressed in sensory neurons, including the ASH, ADF, ASE, ADL, AQR, PQR, URX, and PHA neurons and also at lower frequency in AWC, AFD, and BAG; in ASH, TMC-1 localizes to the cell soma as well as the sensory cilium. | Paper_evidence | WBPaper00041946 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Feb 2013 00:00:00 | ||||||||
| Automated_description | Enables sodium channel activity. Involved in detection of stimulus involved in sensory perception; monoatomic ion transmembrane transport; and sensory perception of chemical stimulus. Located in neuronal cell body; non-motile cilium; and plasma membrane. Expressed in body wall musculature; neurons; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Is an ortholog of human TMC3 (transmembrane channel like 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110520 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16513) | ||||
| DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16513) | ||||||
| DOID:0110563 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16513) | ||||||
| Molecular_info | Corresponding_CDS | T13G4.3 | |||||||
| Corresponding_CDS_history | T13G4.3:wp88 | ||||||||
| T13G4.3:wp128 | |||||||||
| Corresponding_transcript | T13G4.3.1 | ||||||||
| T13G4.3.2 | |||||||||
| Other_sequence (22) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00018692 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00053286 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017899 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00009854 | ||||||||
| WBCnstr00017536 | |||||||||
| WBCnstr00020650 | |||||||||
| WBCnstr00025101 | |||||||||
| WBCnstr00040831 | |||||||||
| WBCnstr00042184 | |||||||||
| WBCnstr00042981 | |||||||||
| Construct_product | WBCnstr00017537 | ||||||||
| WBCnstr00025101 | |||||||||
| WBCnstr00040715 | |||||||||
| Regulate_expr_cluster | WBPaper00065746:tmc-1(rg1003)_downregulated | ||||||||
| WBPaper00065746:tmc-1(rg1003)_upregulated | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (143) | |||||||||
| Interaction (13) | |||||||||
| Anatomy_function | WBbtf0953 | ||||||||
| WBbtf0954 | |||||||||
| WBbtf0956 | |||||||||
| Map_info | Map | X | Position | -18.4825 | |||||
| Positive | Positive_clone | T13G4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
