WormBase Tree Display for Gene: WBGene00020496
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| WBGene00020496 | SMap | S_parent | Sequence | T13H2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | spat-3 | Paper_evidence | WBPaper00027724 | |||||
| Sequence_name | T13H2.5 | ||||||||
| Molecular_name | T13H2.5a | ||||||||
| T13H2.5a.1 | |||||||||
| CE44993 | |||||||||
| T13H2.5b | |||||||||
| CE31236 | |||||||||
| T13H2.5b.1 | |||||||||
| Other_name | CELE_T13H2.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | spat-3 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00020496 | |||||
| WormFlux | gene | WBGene00020496 | |||||||
| NDB | locus_tag | CELE_T13H2.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00020496|UniProtKB=H2KYH3 | |||||||
| family | PTHR46076 | ||||||||
| NCBI | gene | 259704 | |||||||
| RefSeq | protein | NM_001029734.5 | |||||||
| NM_001029733.6 | |||||||||
| SwissProt | UniProtAcc | H2KYH3 | |||||||
| TREEFAM | TREEFAM_ID | TF105501 | |||||||
| UniProt_GCRP | UniProtAcc | H2KYH3 | |||||||
| OMIM | gene | 608985 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 27 Apr 2005 16:54:43 | WBPerson1867 | Event | Acquires_merge | WBGene00020495 | ||||
| 3 | 01 Nov 2006 11:33:19 | WBPerson1847 | Name_change | CGC_name | spat-3 | ||||
| Acquires_merge | WBGene00020495 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spat | ||||||||
| Allele (166) | |||||||||
| Strain | WBStrain00003307 | ||||||||
| WBStrain00035491 | |||||||||
| WBStrain00033902 | |||||||||
| WBStrain00033901 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (25) | |||||||||
| Structured_description | Concise_description | spat-3 encodes, by transcription from alternative promoters, two large(1092- and 2471-residues) proteins; while residues 162-228 of the largerSPAT-3 protein encode a Ring1 type of zinc-finger domain (like that seenin SEX COMBS EXTRA, an E3 ubiquitin-protein ligase RING1 protein ofDrosophila melanogaster), the bulk of SPAT-3 has no obvious similaritiesto other proteins; consistent with its predicted role as a PRC1 component, spat-3 activity is required in vivo for histone H2A ubiquitination; spat-3 is also required for proper positioning of Ray 1 in the male tail, neuronal migration and axon extension, vulval development, and fully wild-type brood sizes; SPAT-3 is also specifically required for PAR protein-dependent cell-polarity, and this requirement is independent ofPAR-2 activity; as with par-3, par-6, pkc-3, and cdc-42, inactivation ofspat-3 (by RNAi or mutation) strongly suppresses the embryonic lethalityof par-2(it5ts) at restrictive temperature; as with nos-3, spat-3 alsosuppresses par-2(lw32), a strong loss-of-function allele; while spat-3par-2 double mutant embryos require PAR-1 for viability, PAR-1 does notregain posterior cortical localization in these embryos, but is insteaddiffused through their cytoplasm. | Paper_evidence | WBPaper00005068 | |||||
| WBPaper00012788 | |||||||||
| WBPaper00012830 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| WBPaper00027724 | |||||||||
| WBPaper00032908 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 04 Mar 2009 00:00:00 | ||||||||
| Automated_description | Enables histone ubiquitin ligase activity. Involved in several processes, including negative regulation of gene expression, epigenetic; negative regulation of vulval development; and nematode male tail tip morphogenesis. Predicted to be part of PcG protein complex and ubiquitin ligase complex. Expressed in several structures, including AIYL; AIYR; SMDDL; and SMDDR. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome and pancreatic ductal carcinoma. Is an ortholog of human RING1 (ring finger protein 1) and RNF2 (ring finger protein 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060037 | Homo sapiens | Paper_evidence | WBPaper00053651 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 Apr 2018 00:00:00 | ||||||||
| Potential_model | DOID:3587 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10061) | |||||
| DOID:0070416 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10061) | ||||||
| Models_disease_in_annotation | WBDOannot00000500 | ||||||||
| Molecular_info | Corresponding_CDS | T13H2.5a | |||||||
| T13H2.5b | |||||||||
| Corresponding_CDS_history | T13H2.5:wp140 | ||||||||
| Corresponding_transcript | T13H2.5a.1 | ||||||||
| T13H2.5b.1 | |||||||||
| Other_sequence (15) | |||||||||
| Associated_feature | WBsf670434 | ||||||||
| WBsf670435 | |||||||||
| WBsf1005000 | |||||||||
| WBsf1005001 | |||||||||
| WBsf1005002 | |||||||||
| WBsf1005003 | |||||||||
| WBsf1022815 | |||||||||
| WBsf1022816 | |||||||||
| WBsf237294 | |||||||||
| WBsf237295 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00077114 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00018696 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063638 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053292 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065860 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053294 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076677 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr6691 | ||||||||
| Expr16284 | |||||||||
| Expr16285 | |||||||||
| Expr1017346 | |||||||||
| Expr1038934 | |||||||||
| Expr1156880 | |||||||||
| Expr2016019 | |||||||||
| Expr2034254 | |||||||||
| Drives_construct | WBCnstr00003778 | ||||||||
| WBCnstr00025099 | |||||||||
| Construct_product | WBCnstr00025099 | ||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (147) | |||||||||
| Interaction (32) | |||||||||
| Map_info | Map | X | Position | -7.1921 | Error | 0.004336 | |||
| Positive | Positive_clone | T13H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
