WormBase Tree Display for Gene: WBGene00021528
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| WBGene00021528 | SMap | S_parent | Sequence | Y41G9A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gbb-1 | Person_evidence | WBPerson6553 | |||||
| Sequence_name | Y41G9A.4 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_Y41G9A.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | gbb-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:04 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 04 Jun 2008 11:48:40 | WBPerson2970 | Name_change | CGC_name | gbb-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gbb | ||||||||
| Allele (187) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00022675 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | gbb-1 encodes, by alternative splicing, one isoform of a subunit of the GABAB receptor dimer (GBB-1/2); GBB-1 is orthologous to human GABBR1 (OMIM:603540); GBB-1/2 is required for inhibition of cholinergic motor neurons by GABA, and thus for normally restrained movement and aldicarb resistance; gbb-1(tm1406) mutants move abnormally fast, with abnormally few changes of direction. | Paper_evidence | WBPaper00031872 | |||||
| WBPaper00032008 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Jul 2011 00:00:00 | ||||||||
| Automated_description | Enables G protein-coupled GABA receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Expressed in nervous system. Is an ortholog of human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9976 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4070) | ||||
| DOID:670 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4070) | ||||||
| DOID:0050742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4070) | ||||||
| DOID:0050741 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4070) | ||||||
| DOID:9975 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4070) | ||||||
| Molecular_info | Corresponding_CDS | Y41G9A.4a | |||||||
| Y41G9A.4b | |||||||||
| Y41G9A.4c | |||||||||
| Y41G9A.4d | |||||||||
| Y41G9A.4e | |||||||||
| Corresponding_CDS_history | Y41G9A.4a:wp245 | ||||||||
| Y41G9A.4b:wp197 | |||||||||
| Y41G9A.4b:wp245 | |||||||||
| Y41G9A.4c:wp245 | |||||||||
| Corresponding_transcript | Y41G9A.4a.1 | ||||||||
| Y41G9A.4b.1 | |||||||||
| Y41G9A.4c.1 | |||||||||
| Y41G9A.4d.1 | |||||||||
| Y41G9A.4e.1 | |||||||||
| Other_sequence (16) | |||||||||
| Associated_feature | WBsf647901 | ||||||||
| WBsf718536 | |||||||||
| WBsf1004487 | |||||||||
| WBsf1004488 | |||||||||
| WBsf1004489 | |||||||||
| WBsf1022546 | |||||||||
| WBsf1022547 | |||||||||
| WBsf235428 | |||||||||
| WBsf235429 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00020509 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00056421 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056422 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00037014 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020508 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077395 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr12898 | ||||||||
| Expr12899 | |||||||||
| Expr1019077 | |||||||||
| Expr1039411 | |||||||||
| Expr1159905 | |||||||||
| Expr2011955 | |||||||||
| Expr2030192 | |||||||||
| Drives_construct | WBCnstr00009864 | ||||||||
| WBCnstr00024519 | |||||||||
| Construct_product | WBCnstr00024519 | ||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (147) | |||||||||
| Interaction | WBInteraction000159519 | ||||||||
| WBInteraction000339683 | |||||||||
| WBInteraction000339750 | |||||||||
| Map_info | Map | X | Position | -12.6689 | Error | 0.000505 | |||
| Positive | Positive_clone | Y41G9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
