WormBase Tree Display for Gene: WBGene00021910
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| WBGene00021910 | SMap | S_parent | Sequence | Y55B1BM | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | stim-1 | Person_evidence | WBPerson1851 | |||||
| Sequence_name | Y55B1BM.1 | ||||||||
| Molecular_name | Y55B1BM.1a | ||||||||
| Y55B1BM.1a.1 | |||||||||
| CE29124 | |||||||||
| Y55B1BM.1b | |||||||||
| CE30055 | |||||||||
| Y55B1BM.1c | |||||||||
| CE34130 | |||||||||
| Y55B1BM.1b.1 | |||||||||
| Y55B1BM.1c.1 | |||||||||
| Other_name | Y55B1BM.c | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y55B1BM.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | stim-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 27 Apr 2006 11:26:11 | WBPerson2970 | Name_change | CGC_name | stim-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | stim | ||||||||
| Allele (170) | |||||||||
| Strain | WBStrain00040176 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | stim-1 encodes an ortholog of STIM1, a putative calcium sensor of theendoplasmic reticulum thought to regulate store-operated calcium entry;stim-1 is required for LIN-3-induced sheath cell contractions, and thusfor ovulation and fertility; like stim-1(RNAi) animals, animalsexpressing constitutively active transgenic STIM-1 are sterile, butunlike stim-1(RNAi), they also defecate abnormally (with an arrhythmicpBoc step); hyperactivated STIM-1 may also perturb osmoregulation andinduce neuronal necrosis; stim-1(RNAi) has no effect on the fertility ofrrf-1 mutants, indicating that STIM-1's role in fertility is purelysomatic; STIM-1 is expressed in spermatheca, gonad sheath cells, uterineepithelial cells, intestine, and head neurons (probably amphid, innerlabial, or both). | Paper_evidence | WBPaper00028479 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 06 Jan 2007 00:00:00 | ||||||||
| Automated_description | Enables calcium channel regulator activity and identical protein binding activity. Involved in several processes, including ovulation; positive regulation of engulfment of apoptotic cell; and store-operated calcium entry. Located in cytoplasm; plasma membrane; and somatodendritic compartment. Expressed in gonadal sheath cell; intestine; spermatheca; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including Stormorken syndrome; gastrointestinal system cancer (multiple); and immunodeficiency 10. Is an ortholog of human STIM1 (stromal interaction molecule 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11386) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11386) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11386) | ||||||
| DOID:9253 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11386) | ||||||
| DOID:0060354 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11386) | ||||||
| DOID:0111970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11386) | ||||||
| DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11386) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11386) | ||||||
| DOID:0080089 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11386) | ||||||
| Molecular_info | Corresponding_CDS | Y55B1BM.1a | |||||||
| Y55B1BM.1b | |||||||||
| Y55B1BM.1c | |||||||||
| Corresponding_transcript | Y55B1BM.1a.1 | ||||||||
| Y55B1BM.1b.1 | |||||||||
| Y55B1BM.1c.1 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf717850 | ||||||||
| WBsf991047 | |||||||||
| WBsf226099 | |||||||||
| WBsf226100 | |||||||||
| WBsf226101 | |||||||||
| WBsf226102 | |||||||||
| Experimental_info | RNAi_result (30) | ||||||||
| Expr_pattern | Expr4260 | ||||||||
| Expr1025960 | |||||||||
| Expr1039625 | |||||||||
| Expr1160939 | |||||||||
| Expr2016964 | |||||||||
| Expr2035112 | |||||||||
| Drives_construct | WBCnstr00000752 | ||||||||
| WBCnstr00011867 | |||||||||
| Construct_product | WBCnstr00000752 | ||||||||
| WBCnstr00011867 | |||||||||
| Microarray_results (35) | |||||||||
| Expression_cluster (101) | |||||||||
| Interaction | WBInteraction000372605 | ||||||||
| WBInteraction000502624 | |||||||||
| WBInteraction000543021 | |||||||||
| WBInteraction000555338 | |||||||||
| WBInteraction000556188 | |||||||||
| WBInteraction000556189 | |||||||||
| WBInteraction000556190 | |||||||||
| WBInteraction000556191 | |||||||||
| Map_info | Map | III | Position | -26.8711 | Error | 0.004644 | |||
| Positive | Positive_clone | Y55B1BM | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
