WormBase Tree Display for Gene: WBGene00022240
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| WBGene00022240 | SMap | S_parent | Sequence | Y73B6BL | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | shl-1 | Paper_evidence | WBPaper00028359 | |||||
| Person_evidence | WBPerson655 | ||||||||
| Sequence_name | Y73B6BL.19 | ||||||||
| Molecular_name | Y73B6BL.19 | ||||||||
| Y73B6BL.19.1 | |||||||||
| CE46429 | |||||||||
| Other_name | CELE_Y73B6BL.19 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | shl-1 | ||||||||
| DB_info | Database | AceView | gene | 4H148 | |||||
| WormQTL | gene | WBGene00022240 | |||||||
| WormFlux | gene | WBGene00022240 | |||||||
| NDB | locus_tag | CELE_Y73B6BL.19 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00022240|UniProtKB=Q95XD1 | |||||||
| family | PTHR11537 | ||||||||
| NCBI | gene | 177400 | |||||||
| RefSeq | protein | NM_068574.5 | |||||||
| TrEMBL | UniProtAcc | Q95XD1 | |||||||
| UniProt_GCRP | UniProtAcc | Q95XD1 | |||||||
| OMIM | gene | 605411 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 22 Sep 2008 14:04:22 | WBPerson2970 | Name_change | CGC_name | shl-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | shl | ||||||||
| Allele (72) | |||||||||
| Strain | WBStrain00001406 | ||||||||
| WBStrain00002186 | |||||||||
| WBStrain00031846 | |||||||||
| WBStrain00051159 | |||||||||
| WBStrain00055286 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (45) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | shl-1 encodes a SHAL/Kv4 ortholog, which encodes voltage-gated potassium channels expressed in muscle; mutations in shl-1 result in loss of all fast transient outward current from muscle cells and, in males, reduced mating efficiency owing to difficulty in locating the hermaphrodite vulva; when expressed in Xenopus oocytes or cultured myocytes, SHL-1 exhibits currents; an SHL-1::GFP reporter fusion is expressed in posterior intestine, body wall muscle, vulval muscle, male-specific diagonal muscles, and a number of motor neurons, interneurons, and sensory neurons. | Paper_evidence | WBPaper00006234 | |||||
| WBPaper00028359 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 Dec 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable A-type (transient outward) potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in dendrite and membrane. Predicted to be part of voltage-gated potassium channel complex. Expressed in body wall musculature; muscle cell; neurons; pharynx; and tail. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Is an ortholog of human KCND2 (potassium voltage-gated channel subfamily D member 2) and KCND3 (potassium voltage-gated channel subfamily D member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6239) | ||||
| DOID:0110226 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6239) | ||||||
| Molecular_info | Corresponding_CDS | Y73B6BL.19 | |||||||
| Corresponding_CDS_history | Y73B6BL.19:wp227 | ||||||||
| Corresponding_transcript | Y73B6BL.19.1 | ||||||||
| Other_sequence (30) | |||||||||
| Associated_feature | WBsf667971 | ||||||||
| WBsf996740 | |||||||||
| WBsf230153 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00086321 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00086318 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086317 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058317 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086080 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002296 | ||||||||
| WBCnstr00004295 | |||||||||
| WBCnstr00004931 | |||||||||
| WBCnstr00004932 | |||||||||
| WBCnstr00010955 | |||||||||
| WBCnstr00013223 | |||||||||
| Construct_product | WBCnstr00004931 | ||||||||
| WBCnstr00004932 | |||||||||
| WBCnstr00013223 | |||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (103) | |||||||||
| Interaction (11) | |||||||||
| Map_info | Map | IV | Position | 3.19243 | Error | 0.000428 | |||
| Positive | Positive_clone | Y73B6BL | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00028359 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00045905 | |||||||||
| WBPaper00046422 | |||||||||
| WBPaper00046461 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00063950 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
