WormBase Tree Display for Gene: WBGene00022639

WBGene00022639 SMap: S_parent: Sequence: ZK6
  Identity: Version: 2
    Name: CGC_name: nhr-253 Person_evidence: WBPerson600
      Sequence_name: ZK6.4
      Molecular_name: ZK6.4
        ZK6.4.1
        CE19643
      Other_name: CELE_ZK6.4 Accession_evidence: NDB BX284605
      Public_name: nhr-253
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:06 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 22 Jul 2005 10:29:12 WBPerson2970 Name_change: CGC_name: nhr-253
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nhr
    Allele (81)
    RNASeq_FPKM (74)
    GO_annotation: 00036542
      00036543
      00036544
      00126677
      00126678
      00126679
      00126680
    Ortholog (19)
    Paralog (222)
    Structured_description: Automated_description: Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in ASEL; ASER; and neurons. Human ortholog(s) of this gene implicated in cholestasis (multiple); liver disease (multiple); and non-alcoholic steatohepatitis. Is an ortholog of human NR1H4 (nuclear receptor subfamily 1 group H member 4) and NR1I3 (nuclear receptor subfamily 1 group I member 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:12236 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7967)
      DOID:0070225 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7967)
      DOID:13619 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7967)
      DOID:0080547 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7967)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7967)
  Molecular_info: Corresponding_CDS: ZK6.4
    Corresponding_transcript: ZK6.4.1
    Associated_feature: WBsf999151
      WBsf1019067
      WBsf1019068
      WBsf231322
      WBsf231323
    Transcription_factor: WBTranscriptionFactor001122
  Experimental_info: RNAi_result: WBRNAi00027081 Inferred_automatically: RNAi_primary
      WBRNAi00027563 Inferred_automatically: RNAi_primary
      WBRNAi00038357 Inferred_automatically: RNAi_primary
      WBRNAi00022080 Inferred_automatically: RNAi_primary
      WBRNAi00027080 Inferred_automatically: RNAi_primary
      WBRNAi00059540 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr7906
      Expr1013426
      Expr1162957
      Expr2014146
      Expr2032388
    Drives_construct: WBCnstr00012983
      WBCnstr00024089
    Construct_product: WBCnstr00024089
    Microarray_results (16)
    Expression_cluster (33)
    Interaction: WBInteraction000176427
      WBInteraction000327261
      WBInteraction000335596
      WBInteraction000377977
      WBInteraction000415531
      WBInteraction000461205
  Map_info: Map: V Position: -19.999
    Positive: Positive_clone: ZK6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5320
        5387
        5417
    Pseudo_map_position
  Reference: WBPaper00030829
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene