WormBase Tree Display for Gene: WBGene00023404
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| WBGene00023404 | Evidence | Person_evidence | WBPerson110 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y47D3B | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | plr-1 | Person_evidence | WBPerson110 | |||||
| Sequence_name | Y47D3B.11 | ||||||||
| Molecular_name | Y47D3B.11 | ||||||||
| Y47D3B.11.1 | |||||||||
| CE33946 | |||||||||
| Other_name | CELE_Y47D3B.11 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | plr-1 | ||||||||
| DB_info | Database | WormFlux | gene | WBGene00023404 | |||||
| NDB | locus_tag | CELE_Y47D3B.11 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00023404|UniProtKB=Q9U2B7 | |||||||
| family | PTHR22765 | ||||||||
| NCBI | gene | 176575 | |||||||
| RefSeq | protein | NM_067072.5 | |||||||
| KEGG | KEGG_id | 2.3.2.- | |||||||
| NemaPath | KEGG_id | 2.3.2.- | |||||||
| SwissProt | UniProtAcc | Q9U2B7 | |||||||
| TREEFAM | TREEFAM_ID | TF317074 | |||||||
| UniProt_GCRP | UniProtAcc | Q9U2B7 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 01 Jun 2004 12:45:23 | WBPerson1845 | Event | Created | |||
| 2 | 20 Jan 2014 09:50:07 | WBPerson2970 | Event | Acquires_merge | WBGene00012944 | ||||
| Name_change | Sequence_name | Y47D3B.11 | |||||||
| Acquires_merge | WBGene00012944 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | plr | ||||||||
| Allele (101) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (31) | |||||||||
| Paralog | WBGene00007666 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00019185 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | plr-1 encodes a transmembrane RING finger protein that is homologous to the mammalian transmembrane E3 ubiquitin ligases RNF43 and ZNRF3; PLR-1 negatively regulates Wnt pathway signaling by downregulating cell surface levels of the Wnt receptors CFZ-2, LIN-17, MIG-1, and MOM-5, as well as CAM-1 and LIN-18; plr-1 is expressed in a subset of head, ventral nerve cord, and tail neurons as well as in the excretory canal and tail epidermis; PLR-1 protein localizes primarily to endosomes. | Paper_evidence | WBPaper00044679 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 01 Apr 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway. Located in Golgi apparatus; early endosome; and late endosome. Expressed in several structures, including egg-laying apparatus; enteric muscle; neurons; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); irritable bowel syndrome; and villous adenoma. Is an ortholog of human RNF43 (ring finger protein 43) and ZNRF3 (zinc and ring finger 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (14) | ||||||||
| Molecular_info | Corresponding_CDS | Y47D3B.11 | |||||||
| Corresponding_CDS_history | Y47D3B.11:wp100 | ||||||||
| Corresponding_transcript | Y47D3B.11.1 | ||||||||
| Other_sequence (19) | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00101325 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00056768 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094790 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00037167 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr11480 | ||||||||
| Expr12085 | |||||||||
| Expr12086 | |||||||||
| Expr12087 | |||||||||
| Expr1019703 | |||||||||
| Expr1035740 | |||||||||
| Expr1160223 | |||||||||
| Expr2014964 | |||||||||
| Expr2033199 | |||||||||
| Drives_construct | WBCnstr00019044 | ||||||||
| WBCnstr00019677 | |||||||||
| WBCnstr00020002 | |||||||||
| WBCnstr00020077 | |||||||||
| WBCnstr00023886 | |||||||||
| Construct_product | WBCnstr00019044 | ||||||||
| WBCnstr00020000 | |||||||||
| WBCnstr00020001 | |||||||||
| WBCnstr00020003 | |||||||||
| WBCnstr00020078 | |||||||||
| WBCnstr00023886 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (98) | |||||||||
| Interaction (12) | |||||||||
| Anatomy_function | WBbtf0848 | ||||||||
| Map_info | Map | III | Position | 9.70776 | |||||
| Positive | Positive_clone | Y47D3B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Reference (11) | |||||||||
| Method | Gene |
