WormBase Tree Display for Gene: WBGene00044631

WBGene00044631 SMap: S_parent: Sequence: F55A11
  Identity: Version: 2
    Name: CGC_name: bus-18 Person_evidence: WBPerson261
            WBPerson2553
      Sequence_name: F55A11.5
      Molecular_name: F55A11.5
        F55A11.5.1
        CE39507
      Other_name: acl-10 Person_evidence: WBPerson1105
        CELE_F55A11.5 Accession_evidence: NDB BX284605
      Public_name: bus-18
    DB_info: Database: WormQTL gene WBGene00044631
        WormFlux gene WBGene00044631
        NDB locus_tag CELE_F55A11.5
        Panther gene CAEEL|WormBase=WBGene00044631|UniProtKB=Q20800
          family PTHR10983
        NCBI gene 186277
        RefSeq protein NM_073570.4
        KEGG KEGG_id 2.3.1.-
        NemaPath KEGG_id 2.3.1.-
        SwissProt UniProtAcc Q20800
        TREEFAM TREEFAM_ID TF314346
        UniProt_GCRP UniProtAcc Q20800
    Species: Caenorhabditis elegans
    History: Version_change: 1 01 Sep 2005 10:24:02 WBPerson2970 Event: Created
        2 24 Oct 2008 14:28:52 WBPerson2970 Event: Acquires_merge: WBGene00010078
              Name_change: Sequence_name: F55A11.5
                Other_name: acl-10
      Acquires_merge: WBGene00010078
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: bus
    Reference_allele: WBVar00145002
    Allele (36)
    Strain: WBStrain00004671
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (35)
    Paralog: WBGene00008581 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00015295 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017888 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019465 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020264 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00022646 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: bus-18 encodes a lysocardiolipin acyltransferase; bus-18 is required for colonization by Microbacterium nematophilum and the tail-swelling response to M. nematophilum infection, as well as for cuticle integrity, traction during movement, full body size, normally rapid growth, and vulval morphogenesis; bus-18 is also needed for normal cuticle antigens and resistance to emetine or colchicine, perhaps because its cuticle is abnormally permeable. Paper_evidence: WBPaper00026735
            WBPaper00029153
            WBPaper00032379
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 10 Dec 2009 00:00:00
      Automated_description: Enables acyltransferase activity. Involved in morphogenesis of an epithelium and phosphatidylinositol metabolic process. Located in endoplasmic reticulum. Expressed in several structures, including AIY; excretory gland cell; hypodermis; interfacial epithelial cell; and vulva. Is an ortholog of human LCLAT1 (lysocardiolipin acyltransferase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F55A11.5
    Corresponding_CDS_history: F55A11.5:wp152
    Corresponding_transcript: F55A11.5.1
    Other_sequence (21)
    Associated_feature: WBsf647295
      WBsf647296
      WBsf661776
      WBsf661777
      WBsf1001440
      WBsf232546
  Experimental_info: RNAi_result: WBRNAi00032833 Inferred_automatically: RNAi_primary
      WBRNAi00048411 Inferred_automatically: RNAi_primary
      WBRNAi00015678 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9096
      Expr9097
      Expr10193
      Expr1028273
      Expr1040293
      Expr1152200
      Expr2009685
      Expr2027924
    Drives_construct: WBCnstr00007266
      WBCnstr00007268
      WBCnstr00007269
      WBCnstr00007270
      WBCnstr00008330
      WBCnstr00013715
      WBCnstr00013716
      WBCnstr00037809
    Construct_product: WBCnstr00007249
      WBCnstr00007264
      WBCnstr00007266
      WBCnstr00007268
      WBCnstr00007269
      WBCnstr00008330
      WBCnstr00013716
      WBCnstr00037809
    Microarray_results (21)
    Expression_cluster: WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00040560:hpl-2_L3_upregulated
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00043945:MeHg_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046024:sleep_downregulated_oscillating
      WBPaper00046121:ecdoderm_unique
      WBPaper00048611:MnCl2_upregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00051558:aging_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056169:rrf-3(pk1426)_upregulated_L1
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056617:adr-1_upregulated_L4_transcript
      WBPaper00056826:SGP_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060445:ikb-1(nr2027)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADEsh
      WBPaper00061340:AIY
      WBPaper00061340:AMso
      WBPaper00061340:CEPso
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp1V_and_ant_arc_V
      WBPaper00061340:hyp1_hyp2
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:ILso
      WBPaper00061340:P_cell
      WBPaper00061340:Tail_hypodermis
      WBPaper00061340:Y
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:mlt-9_22518-F33D4.6_14044
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061651:AIY_enriched
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062534:fat-P-80_downregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065005:sams-3(RNAi)_upregulated
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065841:57_0
      WBPaper00065841:112_0
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_4
      cgc4489_group_5
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00032948:FedUp
      WBPaper00032948:MoltOssilate
      WBPaper00034739:N2lessDR1350
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_G
      WBPaper00040185:nhr-23(RNAi)_downregulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041207:CE_dauer_down
      WBPaper00041267:SpaceFlight_Downregulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (16)
    WBProcess: WBbiopr:00000039
  Map_info: Map: V Position: 3.37994 Error: 0.010316
    Positive: Positive_clone: F55A11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5473
        4844
        4808
        4636
        5619
  Reference (15)
  Method: Gene