WormBase Tree Display for Gene: WBGene00045237
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| WBGene00045237 | SMap | S_parent | Sequence | F39H2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mrt-1 | Paper_evidence | WBPaper00035222 | |||||
| Person_evidence | WBPerson261 | ||||||||
| WBPerson7 | |||||||||
| Sequence_name | F39H2.5 | ||||||||
| Molecular_name | F39H2.5 | ||||||||
| F39H2.5.1 | |||||||||
| CE30531 | |||||||||
| Other_name | CELE_F39H2.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mrt-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 Jan 2007 14:53:24 | WBPerson480 | Event | Created | |||
| 2 | 10 Nov 2009 16:03:51 | WBPerson1847 | Event | Acquires_merge | WBGene00009564 | ||||
| Acquires_merge | WBGene00009564 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mrt | ||||||||
| Allele (35) | |||||||||
| Strain | WBStrain00040705 | ||||||||
| WBStrain00040706 | |||||||||
| WBStrain00040709 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00007065 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00010195 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mrt-1 encodes a protein that contains an N-terminal domain homologous to the second OB DNA-binding fold of POT1 (Protection Of Telomeres 1)telomere-binding proteins and a C-terminal domain homologous to the SNM1 family nuclease domain; MRT-1 activity is required in vivo for regulation of telomere length and nucleotide excision repair (DNA crosslink repair); in vitro, MRT-1 exhibits 3'-5' exonuclease activity and single-stranded DNA-binding activity. | Paper_evidence | WBPaper00035222 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Jan 2010 00:00:00 | ||||||||
| Automated_description | Enables 3'-5' exonuclease activity and single-stranded DNA binding activity. Involved in nucleotide-excision repair; reproduction; and telomere maintenance via telomerase. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in dyskeratosis congenita. Is an ortholog of human DCLRE1B (DNA cross-link repair 1B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2729 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17641) | ||||
| Molecular_info | Corresponding_CDS | F39H2.5 | |||||||
| Corresponding_transcript | F39H2.5.1 | ||||||||
| Associated_feature | WBsf643539 | ||||||||
| WBsf218191 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00003642 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00007733 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00046806 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077840 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1025750 | ||||||||
| Expr1040351 | |||||||||
| Expr1150681 | |||||||||
| Expr2013761 | |||||||||
| Expr2031996 | |||||||||
| Drives_construct | WBCnstr00023293 | ||||||||
| Construct_product | WBCnstr00023293 | ||||||||
| Antibody | WBAntibody00001984 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction | WBInteraction000008924 | ||||||||
| WBInteraction000571757 | |||||||||
| WBInteraction000571761 | |||||||||
| Map_info | Map | I | Position | 3.01633 | Error | 0.000295 | |||
| Positive | Positive_clone | F39H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
