WormBase Tree Display for Gene: WBGene00077701

WBGene00077701 SMap: S_parent: Sequence: E01A2
  Identity: Version: 2
    Name: CGC_name: poml-3 Person_evidence: WBPerson10017
            WBPerson95
      Sequence_name: E01A2.10
      Molecular_name: E01A2.10
        E01A2.10.1
        CE20637
      Other_name: CELE_E01A2.10 Accession_evidence: NDB BX284601
      Public_name: poml-3
    DB_info: Database: AceView gene 1E714
        WormFlux gene WBGene00077701
        NDB locus_tag CELE_E01A2.10
        Panther gene CAEEL|WormBase=WBGene00077701|UniProtKB=B1V898
          family PTHR11799
        NCBI gene 6418581
        RefSeq protein NM_001128968.4
        TREEFAM TREEFAM_ID TF322436
        TrEMBL UniProtAcc B1V898
        UniProt_GCRP UniProtAcc B1V898
    Species: Caenorhabditis elegans
    History: Version_change: 1 27 Mar 2008 16:32:36 WBPerson1867 Event: Split_from: WBGene00017090
        2 13 Apr 2012 16:55:20 WBPerson2970 Name_change: CGC_name: poml-3
      Split_from: WBGene00017090
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: poml
    Allele (24)
    Strain: WBStrain00037689
    RNASeq_FPKM (74)
    Ortholog (60)
    Paralog: WBGene00003170 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010775 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00017089 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00044697 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Automated_description: Enriched in ABplapaaaa; ABprapaaaa; and intestine based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and skn-1 based on microarray; RNA-seq; and proteomic studies. Is affected by twenty-one chemicals including manganese chloride; D-glucose; and 4-bromodiphenyl ether based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); eye disease (multiple); and hematologic cancer (multiple). Human PON1 enables several functions, including aryldialkylphosphatase activity; arylesterase activity; and protein homodimerization activity. Is predicted to encode a protein with the following domains: SMP-30/Gluconolactonase/LRE-like region and Six-bladed beta-propeller, TolB-like. Is an ortholog of human PON1 (paraoxonase 1); PON2 (paraoxonase 2); and PON3 (paraoxonase 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (51)
  Molecular_info: Corresponding_CDS: E01A2.10
    Corresponding_transcript: E01A2.10.1
    Other_sequence (19)
    Associated_feature: WBsf649078
      WBsf219244
  Experimental_info: RNAi_result: WBRNAi00030449 Inferred_automatically: RNAi_primary
      WBRNAi00043562 Inferred_automatically: RNAi_primary
      WBRNAi00003304 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1013946
      Expr1147549
      Expr2014998
      Expr2033233
    Microarray_results (14)
    Expression_cluster (195)
    Interaction: WBInteraction000551764
      WBInteraction000563329
      WBInteraction000571027
      WBInteraction000585873
  Map_info: Map: I Position: -1.6977
    Positive: Positive_clone: E01A2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00065080
    WBPaper00065331
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene