WormBase Tree Display for Interaction: WBInteraction000001327
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| WBInteraction000001327 | Interaction_type | Genetic | Synthetic | ||
|---|---|---|---|---|---|
| GI_module_one | A_phenotypic | ||||
| GI_module_three | Diverging | ||||
| Interactor | Interactor_overlapping_gene | WBGene00004946 | Interactor_type | Non_directional | |
| WBGene00001081 | Interactor_type | Non_directional | |||
| Variation_interactor | WBVar00000597 | Interactor_type | Non_directional | ||
| WBVar00000595 | Interactor_type | Non_directional | |||
| Interaction_summary | "We analyzed double mutants of sop-3(bx96) with a strong allele of sop-1 and found that this combination is synthetic lethal. Whereas sop-3 and sop-1 mutations singly have little effect (<5%, n>1000) on viability, in sop-3(bx96); sop-1(bx92) double mutants, 50% of embryos do not hatch (n=2762) and 78% of hatching animals die at an early larval stage (n=1318). Since neither sop-3(bx96) nor sop-1(bx92) appear to be null alleles, this synthetic lethal phenotype, together with the nearly identical genetic properties of the two genes, suggest that sop-3 and sop-1 act in a single pathway." | ||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0000062 | ||||
| Paper | WBPaper00004616 |
