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WormBase Tree Display for Interaction: WBInteraction000501526

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Name Class

WBInteraction000501526Interaction_typeRegulatory
InteractorInteractor_overlapping_geneWBGene00000244Interactor_typeTrans_regulator
WBGene00003892Interactor_typeTrans_regulator
WBGene00000490Interactor_typeTrans_regulated
WBGene00003885Interactor_typeTrans_regulated
Interaction_summaryWhen the same osm-5::gfp and che-11::gfp transgenes are expressed in the osm-12 and bbs-8 mutant backgrounds, the GFP-tagged proteins show abnormal localization patterns. In the bbs-8 mutant, the localization of OSM-5::GFP along the ciliary axonomes is highly reduced, and a significant number of worms display disorganized accumulation of this marker within the transition zone region, as well as the dendrites and cell bodies. Although some OSM-5::GFP appears to enter the ciliary axonemes of a significant number of osm-12 mutant animals, its overall localization pattern appears disorganized, with poorly defined transition zones and a high level of diffuse staining in the dendrites and cell bodies. The localization of the CHE-11::GFP marker to the ciliary axonemes is also highly reduced in the bbs-8 and osm-12 mutants, but the marker is still present and apparently organized in the transition zone region of both mutants.
Detection_methodReporter_gene[osm-5::gfp] translational fusion.
Regulation_resultPositive_regulateSubcellular_localizationciliary transition zones and axonemes
PaperWBPaper00024240