WormBase Tree Display for Interaction: WBInteraction000501526
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WBInteraction000501526 | Interaction_type | Regulatory | |||
---|---|---|---|---|---|
Interactor | Interactor_overlapping_gene | WBGene00000244 | Interactor_type | Trans_regulator | |
WBGene00003892 | Interactor_type | Trans_regulator | |||
WBGene00000490 | Interactor_type | Trans_regulated | |||
WBGene00003885 | Interactor_type | Trans_regulated | |||
Interaction_summary | When the same osm-5::gfp and che-11::gfp transgenes are expressed in the osm-12 and bbs-8 mutant backgrounds, the GFP-tagged proteins show abnormal localization patterns. In the bbs-8 mutant, the localization of OSM-5::GFP along the ciliary axonomes is highly reduced, and a significant number of worms display disorganized accumulation of this marker within the transition zone region, as well as the dendrites and cell bodies. Although some OSM-5::GFP appears to enter the ciliary axonemes of a significant number of osm-12 mutant animals, its overall localization pattern appears disorganized, with poorly defined transition zones and a high level of diffuse staining in the dendrites and cell bodies. The localization of the CHE-11::GFP marker to the ciliary axonemes is also highly reduced in the bbs-8 and osm-12 mutants, but the marker is still present and apparently organized in the transition zone region of both mutants. | ||||
Detection_method | Reporter_gene | [osm-5::gfp] translational fusion. | |||
Regulation_result | Positive_regulate | Subcellular_localization | ciliary transition zones and axonemes | ||
Paper | WBPaper00024240 |