WormBase Tree Display for Interaction: WBInteraction000502241
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| WBInteraction000502241 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003001 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr631 | ||||
| Transgene | WBTransgene00000059 | ||||
| Construct | WBCnstr00000059 | ||||
| WBGene00007009 | Interactor_type | Trans_regulator | |||
| Interaction_summary | About 62% of wwp-1(RNAi) hermaphrodites failed to downregulate LIN-12(+)::GFP, as opposed to 14% of lacZ(RNAi) hermaphrodites. This difference indicates that wwp-1 is required for LIN-12 downregulation. Additionally, LIN-12(+)::GFP was still able to accumulate in intracellular puncta in wwp-1(RNAi) hermaphrodites. These results suggest that wwp-1 is required for LIN-12 downregulation at a post-internalization step. | ||||
| Detection_method | Construct | ||||
| Reporter_gene | [lin-12g::lin-12(+)::gfp] translational fusion. | ||||
| Transgene | |||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Negative_regulate | Anatomy_term | WBbt:0006987 | ||
| WBbt:0006988 | |||||
| Subcellular_localization | intracellular puncta | ||||
| Paper | WBPaper00026869 |
