WormBase Tree Display for Interaction: WBInteraction000525112
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| WBInteraction000525112 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00004267 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr3546 | ||||
| Transgene | WBTransgene00020127 | ||||
| Construct | WBCnstr00019529 | ||||
| WBGene00004921 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00088818 | Interactor_type | Trans_regulator | ||
| Interaction_summary | In snt-1(md290) animals, which lack snt-1 function, the GFP::RAB-3 puncta disappeared and the GFP signal was diffusely distributed throughout the neuronal processes... In wild type, RAB-3 is highly enriched in membrane fractions, which is consistent with the SV localization of GTP-RAB-3. In contrast, the RAB-3 protein distribution is shifted to the soluble fraction when sent-1 is removed, suggesting a cytosolic localization of RAB-1 in snt-1 mutants. | ||||
| Detection_method | Construct | ||||
| Transgene | |||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0003679 | ||
| Subcellular_localization | synaptic vesicle | ||||
| Paper | WBPaper00046486 |
